The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy

There has been no reliable marker for predicting oncological outcomes in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (NACRT). We retrospectively analyzed 73 patients with LARC who underwent curative surgery after NACRT. The modified Glasgow prognostic...

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Autores principales: Shimada, Atsushi, Matsuda, Takeru, Sawada, Ryuichiro, Hasegawa, Hiroshi, Yamashita, Kimihiro, Harada, Hitoshi, Urakawa, Naoki, Goto, Hironobu, Kanaji, Shingo, Oshikiri, Taro, Kakeji, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564952/
https://www.ncbi.nlm.nih.gov/pubmed/37816855
http://dx.doi.org/10.1038/s41598-023-44431-w
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author Shimada, Atsushi
Matsuda, Takeru
Sawada, Ryuichiro
Hasegawa, Hiroshi
Yamashita, Kimihiro
Harada, Hitoshi
Urakawa, Naoki
Goto, Hironobu
Kanaji, Shingo
Oshikiri, Taro
Kakeji, Yoshihiro
author_facet Shimada, Atsushi
Matsuda, Takeru
Sawada, Ryuichiro
Hasegawa, Hiroshi
Yamashita, Kimihiro
Harada, Hitoshi
Urakawa, Naoki
Goto, Hironobu
Kanaji, Shingo
Oshikiri, Taro
Kakeji, Yoshihiro
author_sort Shimada, Atsushi
collection PubMed
description There has been no reliable marker for predicting oncological outcomes in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (NACRT). We retrospectively analyzed 73 patients with LARC who underwent curative surgery after NACRT. The modified Glasgow prognostic score (mGPS) was assessed after NACRT, and clinical outcomes were compared between the high (mGPS = 1 or 2; n = 23) and low (mGPS = 0; n = 50) groups. Body mass index was significantly higher in the low mGPS group. The 5-year disease-free survival (DFS) rate was significantly worse in the high mGPS group than that in the low mGPS group (36.7% vs. 76.6%, p = 0.002). Univariate and multivariate analyses of DFS revealed that mGPS was the most significant predictor (p < 0.001). mGPS appears to be a reliable predictor of oncological outcomes in patients with LARC undergoing NACRT.
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spelling pubmed-105649522023-10-12 The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy Shimada, Atsushi Matsuda, Takeru Sawada, Ryuichiro Hasegawa, Hiroshi Yamashita, Kimihiro Harada, Hitoshi Urakawa, Naoki Goto, Hironobu Kanaji, Shingo Oshikiri, Taro Kakeji, Yoshihiro Sci Rep Article There has been no reliable marker for predicting oncological outcomes in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (NACRT). We retrospectively analyzed 73 patients with LARC who underwent curative surgery after NACRT. The modified Glasgow prognostic score (mGPS) was assessed after NACRT, and clinical outcomes were compared between the high (mGPS = 1 or 2; n = 23) and low (mGPS = 0; n = 50) groups. Body mass index was significantly higher in the low mGPS group. The 5-year disease-free survival (DFS) rate was significantly worse in the high mGPS group than that in the low mGPS group (36.7% vs. 76.6%, p = 0.002). Univariate and multivariate analyses of DFS revealed that mGPS was the most significant predictor (p < 0.001). mGPS appears to be a reliable predictor of oncological outcomes in patients with LARC undergoing NACRT. Nature Publishing Group UK 2023-10-10 /pmc/articles/PMC10564952/ /pubmed/37816855 http://dx.doi.org/10.1038/s41598-023-44431-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Shimada, Atsushi
Matsuda, Takeru
Sawada, Ryuichiro
Hasegawa, Hiroshi
Yamashita, Kimihiro
Harada, Hitoshi
Urakawa, Naoki
Goto, Hironobu
Kanaji, Shingo
Oshikiri, Taro
Kakeji, Yoshihiro
The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
title The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
title_full The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
title_fullStr The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
title_full_unstemmed The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
title_short The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
title_sort modified glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564952/
https://www.ncbi.nlm.nih.gov/pubmed/37816855
http://dx.doi.org/10.1038/s41598-023-44431-w
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