Post COVID sequelae among COVID-19 survivors: insights from the Indian National Clinical Registry for COVID-19

INTRODUCTION: The effects of COVID-19 infection persist beyond the active phase. Comprehensive description and analysis of the post COVID sequelae in various population groups are critical to minimise the long-term morbidity and mortality associated with COVID-19. This analysis was conducted with an...

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Detalles Bibliográficos
Autores principales: Kumar, Gunjan, Bhalla, Ashish, Mukherjee, Aparna, Turuk, Alka, Talukdar, Arunansu, Mukherjee, Subhasis, Bhardwaj, Pankaj, Menon, Geetha R, Sahu, Damodar, Misra, Puspender, Sharma, Lokesh Kumar, Mohindra, Ritin, S, Samita, Suri, Vikas, Das, Himadri, Sarkar, Debasis, Ghosh, Soumyadeep, Ghosh, Priyanka, Dutta, Moumita, Chakraborty, Shreetama, Kumar, Deepak, Gupta, Manoj Kumar, Goel, Akhil Dhanesh, Baruah, Tridip Dutta, Kannauje, Pankaj Kumar, Shukla, Arvind Kumar, Khambholja, Janakkumar R, Patel, Amit, Shah, Nitesh, Bhuniya, Sourin, Panigrahi, Manoj Kumar, Mohapatra, Prasanta Raghab, Pathak, Ashish, Sharma, Ashish, John, Mary, Kaur, Kiranpreet, Nongpiur, Vijay, Pala, Star, Shivnitwar, Sachin K, Krishna, Bobba Rohil, Dulhani, Naveen, Gupta, Balkishan, Gupta, Jigyasa, Bhandari, Sudhir, Agrawal, Abhishek, Aggarwal, H K, Jain, Deepak, Shah, Arti D, Naik, Parshwa, Panchal, Manisha, Anderpa, Mayank, Kikon, Nyanthung, Humtsoe, Christina Nzani, Sharma, Nikita, Vohra, Rajaat, Patnaik, Lipilekha, Sahoo, Jagdish Prasad, Joshi, Rajnish, Kokane, Arun, Ray, Yogiraj, Rajvansh, Kruti, Purohit, Hemang M, Shah, Nehal M, Madharia, Arun, Dube, Simmi, Shrivastava, Neha, Kataria, Sushila, Shameem, Mohammad, Fatima, Nazish, Ghosh, Saumitra, Hazra, Avijit, D, Himanshu, Salgar, Veeresh B, Algur, Santosh, M L, Kala Yadhav, M, Pavan Kumar, Panda, Samiran, Vishnu Vardhana Rao, Mendu, Bhargava, Balram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565174/
https://www.ncbi.nlm.nih.gov/pubmed/37816536
http://dx.doi.org/10.1136/bmjgh-2023-012245
Descripción
Sumario:INTRODUCTION: The effects of COVID-19 infection persist beyond the active phase. Comprehensive description and analysis of the post COVID sequelae in various population groups are critical to minimise the long-term morbidity and mortality associated with COVID-19. This analysis was conducted with an objective to estimate the frequency of post COVID sequelae and subsequently, design a framework for holistic management of post COVID morbidities. METHODS: Follow-up data collected as part of a registry-based observational study in 31 hospitals across India since September 2020–October 2022 were used for analysis. All consenting hospitalised patients with COVID-19 are telephonically followed up for up to 1 year post-discharge, using a prestructured form focused on symptom reporting. RESULTS: Dyspnoea, fatigue and mental health issues were reported among 18.6%, 10.5% and 9.3% of the 8042 participants at first follow-up of 30–60 days post-discharge, respectively, which reduced to 11.9%, 6.6% and 9%, respectively, at 1-year follow-up in 2192 participants. Patients who died within 90 days post-discharge were significantly older (adjusted OR (aOR): 1.02, 95% CI: 1.01, 1.03), with at least one comorbidity (aOR: 1.76, 95% CI: 1.31, 2.35), and a higher proportion had required intensive care unit admission during the initial hospitalisation due to COVID-19 (aOR: 1.49, 95% CI: 1.08, 2.06) and were discharged at WHO ordinal scale 6–7 (aOR: 49.13 95% CI: 25.43, 94.92). Anti-SARS-CoV-2 vaccination (at least one dose) was protective against such post-discharge mortality (aOR: 0.19, 95% CI: 0.01, 0.03). CONCLUSION: Hospitalised patients with COVID-19 experience a variety of long-term sequelae after discharge from hospitals which persists although in reduced proportions until 12 months post-discharge. Developing a holistic management framework with engagement of care outreach workers as well as teleconsultation is a way forward in effective management of post COVID morbidities as well as reducing mortality.

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