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Anti-inflammatory and analgesic effects of Streblus indicus
The bark of Streblus indicus, a Dai medicine in China, has been listed in the Chinese Materia Medica as possessing hemostatic and analgesic properties. Ethnic medicine books record that its bark or leaves for the treatment of mumps and lymphoma. However, according to the literature survey, anti-infl...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565225/ https://www.ncbi.nlm.nih.gov/pubmed/37829300 http://dx.doi.org/10.3389/fphar.2023.1249234 |
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author | Xie, Yan-Qing Huang, Jing-Yao Chen, Yun-Xiu Zhou, Qian Zhou, Qi-Xiu Yang, Zhu-Ya Xu, Shi-Kui Tan, Wen-Hong Liu, Lu |
author_facet | Xie, Yan-Qing Huang, Jing-Yao Chen, Yun-Xiu Zhou, Qian Zhou, Qi-Xiu Yang, Zhu-Ya Xu, Shi-Kui Tan, Wen-Hong Liu, Lu |
author_sort | Xie, Yan-Qing |
collection | PubMed |
description | The bark of Streblus indicus, a Dai medicine in China, has been listed in the Chinese Materia Medica as possessing hemostatic and analgesic properties. Ethnic medicine books record that its bark or leaves for the treatment of mumps and lymphoma. However, according to the literature survey, anti-inflammatory and analgesic studies available for leaves and branches of S. indicus have been seldom reported so far. The current study focuses on the metabolites of S. indicus bark and leaves responsible for anti-inflammatory and analgesic effects on the basis of bioactive-included acetic acid writhing, hot-plate, and xylene-induced ear swelling. The secretion of inflammatory mediators, TNF-α, IL-6, IL-1β, IL-4, and IL-10, were evaluated for their anti-inflammatory by xylene-induced in mouse ear cells. Histological examination was used to assess the anti-inflammatory and analgesic effects of the branches and leaves of S. indicus, and Western blot analysis determined the mechanism of the methanolic extract of branches and leaves. Different metabolites of S. indicus significantly alleviated analgesic and anti-inflammatory effects, with no discernable differences among them. All metabolites decreased the levels of TNF-α, IL-1β, and IL-6 and increased the levels of IL-4 and IL-10. The analgesic and anti-inflammatory mechanism of the methanolic extract was related to the NF-kB signaling pathway. These results not only would account for scientific knowledge for the traditional application of S. indicus, but also provide a credible theoretical foundation for the further development of anti-inflammatory and analgesic agents. |
format | Online Article Text |
id | pubmed-10565225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105652252023-10-12 Anti-inflammatory and analgesic effects of Streblus indicus Xie, Yan-Qing Huang, Jing-Yao Chen, Yun-Xiu Zhou, Qian Zhou, Qi-Xiu Yang, Zhu-Ya Xu, Shi-Kui Tan, Wen-Hong Liu, Lu Front Pharmacol Pharmacology The bark of Streblus indicus, a Dai medicine in China, has been listed in the Chinese Materia Medica as possessing hemostatic and analgesic properties. Ethnic medicine books record that its bark or leaves for the treatment of mumps and lymphoma. However, according to the literature survey, anti-inflammatory and analgesic studies available for leaves and branches of S. indicus have been seldom reported so far. The current study focuses on the metabolites of S. indicus bark and leaves responsible for anti-inflammatory and analgesic effects on the basis of bioactive-included acetic acid writhing, hot-plate, and xylene-induced ear swelling. The secretion of inflammatory mediators, TNF-α, IL-6, IL-1β, IL-4, and IL-10, were evaluated for their anti-inflammatory by xylene-induced in mouse ear cells. Histological examination was used to assess the anti-inflammatory and analgesic effects of the branches and leaves of S. indicus, and Western blot analysis determined the mechanism of the methanolic extract of branches and leaves. Different metabolites of S. indicus significantly alleviated analgesic and anti-inflammatory effects, with no discernable differences among them. All metabolites decreased the levels of TNF-α, IL-1β, and IL-6 and increased the levels of IL-4 and IL-10. The analgesic and anti-inflammatory mechanism of the methanolic extract was related to the NF-kB signaling pathway. These results not only would account for scientific knowledge for the traditional application of S. indicus, but also provide a credible theoretical foundation for the further development of anti-inflammatory and analgesic agents. Frontiers Media S.A. 2023-09-27 /pmc/articles/PMC10565225/ /pubmed/37829300 http://dx.doi.org/10.3389/fphar.2023.1249234 Text en Copyright © 2023 Xie, Huang, Chen, Zhou, Zhou, Yang, Xu, Tan and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Xie, Yan-Qing Huang, Jing-Yao Chen, Yun-Xiu Zhou, Qian Zhou, Qi-Xiu Yang, Zhu-Ya Xu, Shi-Kui Tan, Wen-Hong Liu, Lu Anti-inflammatory and analgesic effects of Streblus indicus |
title | Anti-inflammatory and analgesic effects of Streblus indicus
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title_full | Anti-inflammatory and analgesic effects of Streblus indicus
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title_fullStr | Anti-inflammatory and analgesic effects of Streblus indicus
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title_full_unstemmed | Anti-inflammatory and analgesic effects of Streblus indicus
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title_short | Anti-inflammatory and analgesic effects of Streblus indicus
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title_sort | anti-inflammatory and analgesic effects of streblus indicus |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565225/ https://www.ncbi.nlm.nih.gov/pubmed/37829300 http://dx.doi.org/10.3389/fphar.2023.1249234 |
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