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Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide

Deoxycholate (DA) is a natural emulsifying agent involved in the absorption of dietary lipids. Due to the facial distribution of hydrophobic-hydrophilic region, DA easily aggregates under ambient conditions, and this property hinders the practical application of DA in clinical applications. In this...

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Autores principales: Lee, Kyounghyoun, Xie, Jing, Park, Hyeonjin, Jung, Hyun, Oh, Jae-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565365/
https://www.ncbi.nlm.nih.gov/pubmed/37830016
http://dx.doi.org/10.1098/rsos.230506
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author Lee, Kyounghyoun
Xie, Jing
Park, Hyeonjin
Jung, Hyun
Oh, Jae-Min
author_facet Lee, Kyounghyoun
Xie, Jing
Park, Hyeonjin
Jung, Hyun
Oh, Jae-Min
author_sort Lee, Kyounghyoun
collection PubMed
description Deoxycholate (DA) is a natural emulsifying agent involved in the absorption of dietary lipids. Due to the facial distribution of hydrophobic-hydrophilic region, DA easily aggregates under ambient conditions, and this property hinders the practical application of DA in clinical applications. In this study, we found that the molecular arrangement of DA molecules could be controlled by using layered double hydroxide (LDH) under a specific reaction condition. The effect of reaction methods such as co-precipitation, ion exchange and reconstruction on the molecular arrangement of DA was investigated by X-ray diffraction, Fourier-transform infrared spectroscopy, high-resolution transmission electron microscopy and differential scanning calorimetry. It was demonstrated that the self-aggregation of DA molecules could be suppressed by the oriented arrangement of DA between the gallery space of LDH. The DA moiety was well stabilized in the LDH layers due to the electrostatic interaction between DA molecules and LDH layers. The most ordered arrangement of DA molecules was observed when DA was incorporated into LDH via a reconstruction method. The DA molecules arranged in LDH via reconstruction did not show significant exothermic or endothermic behaviour up to 400°C, showing that the DA moiety lost its intermolecular attraction in between LDH layers.
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spelling pubmed-105653652023-10-12 Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide Lee, Kyounghyoun Xie, Jing Park, Hyeonjin Jung, Hyun Oh, Jae-Min R Soc Open Sci Chemistry Deoxycholate (DA) is a natural emulsifying agent involved in the absorption of dietary lipids. Due to the facial distribution of hydrophobic-hydrophilic region, DA easily aggregates under ambient conditions, and this property hinders the practical application of DA in clinical applications. In this study, we found that the molecular arrangement of DA molecules could be controlled by using layered double hydroxide (LDH) under a specific reaction condition. The effect of reaction methods such as co-precipitation, ion exchange and reconstruction on the molecular arrangement of DA was investigated by X-ray diffraction, Fourier-transform infrared spectroscopy, high-resolution transmission electron microscopy and differential scanning calorimetry. It was demonstrated that the self-aggregation of DA molecules could be suppressed by the oriented arrangement of DA between the gallery space of LDH. The DA moiety was well stabilized in the LDH layers due to the electrostatic interaction between DA molecules and LDH layers. The most ordered arrangement of DA molecules was observed when DA was incorporated into LDH via a reconstruction method. The DA molecules arranged in LDH via reconstruction did not show significant exothermic or endothermic behaviour up to 400°C, showing that the DA moiety lost its intermolecular attraction in between LDH layers. The Royal Society 2023-10-11 /pmc/articles/PMC10565365/ /pubmed/37830016 http://dx.doi.org/10.1098/rsos.230506 Text en © 2023 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Lee, Kyounghyoun
Xie, Jing
Park, Hyeonjin
Jung, Hyun
Oh, Jae-Min
Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
title Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
title_full Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
title_fullStr Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
title_full_unstemmed Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
title_short Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
title_sort controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565365/
https://www.ncbi.nlm.nih.gov/pubmed/37830016
http://dx.doi.org/10.1098/rsos.230506
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