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Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease
Most eukaryotic cells have mitochondrial networks that can change in shape, distribution, and size depending on cellular metabolic demands and environments. Mitochondrial quality control is critical for various mitochondrial functions including energy production, redox homeostasis, intracellular cal...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Nephrology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565453/ https://www.ncbi.nlm.nih.gov/pubmed/37448292 http://dx.doi.org/10.23876/j.krcp.22.233 |
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author | Baek, Jihyun Lee, Yu Ho Jeong, Hye Yun Lee, So-Young |
author_facet | Baek, Jihyun Lee, Yu Ho Jeong, Hye Yun Lee, So-Young |
author_sort | Baek, Jihyun |
collection | PubMed |
description | Most eukaryotic cells have mitochondrial networks that can change in shape, distribution, and size depending on cellular metabolic demands and environments. Mitochondrial quality control is critical for various mitochondrial functions including energy production, redox homeostasis, intracellular calcium handling, cell differentiation, proliferation, and cell death. Quality control mechanisms within mitochondria consist of antioxidant defenses, protein quality control, DNA damage repair systems, mitochondrial fusion and fission, mitophagy, and mitochondrial biogenesis. Defects in mitochondrial quality control and disruption of mitochondrial homeostasis are common characteristics of various kidney cell types under hyperglycemic conditions. Such defects contribute to diabetes-induced pathologies in renal tubular cells, podocytes, endothelial cells, and immune cells. In this review, we focus on the roles of mitochondrial quality control in diabetic kidney disease pathogenesis and discuss current research evidence and future directions. |
format | Online Article Text |
id | pubmed-10565453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Society of Nephrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-105654532023-10-12 Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease Baek, Jihyun Lee, Yu Ho Jeong, Hye Yun Lee, So-Young Kidney Res Clin Pract Review Article Most eukaryotic cells have mitochondrial networks that can change in shape, distribution, and size depending on cellular metabolic demands and environments. Mitochondrial quality control is critical for various mitochondrial functions including energy production, redox homeostasis, intracellular calcium handling, cell differentiation, proliferation, and cell death. Quality control mechanisms within mitochondria consist of antioxidant defenses, protein quality control, DNA damage repair systems, mitochondrial fusion and fission, mitophagy, and mitochondrial biogenesis. Defects in mitochondrial quality control and disruption of mitochondrial homeostasis are common characteristics of various kidney cell types under hyperglycemic conditions. Such defects contribute to diabetes-induced pathologies in renal tubular cells, podocytes, endothelial cells, and immune cells. In this review, we focus on the roles of mitochondrial quality control in diabetic kidney disease pathogenesis and discuss current research evidence and future directions. The Korean Society of Nephrology 2023-09 2023-05-22 /pmc/articles/PMC10565453/ /pubmed/37448292 http://dx.doi.org/10.23876/j.krcp.22.233 Text en Copyright © 2023 The Korean Society of Nephrology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial and No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) which permits unrestricted non-commercial use, distribution of the material without any modifications, and reproduction in any medium, provided the original works properly cited. |
spellingShingle | Review Article Baek, Jihyun Lee, Yu Ho Jeong, Hye Yun Lee, So-Young Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease |
title | Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease |
title_full | Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease |
title_fullStr | Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease |
title_full_unstemmed | Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease |
title_short | Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease |
title_sort | mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565453/ https://www.ncbi.nlm.nih.gov/pubmed/37448292 http://dx.doi.org/10.23876/j.krcp.22.233 |
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