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Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease

Most eukaryotic cells have mitochondrial networks that can change in shape, distribution, and size depending on cellular metabolic demands and environments. Mitochondrial quality control is critical for various mitochondrial functions including energy production, redox homeostasis, intracellular cal...

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Detalles Bibliográficos
Autores principales: Baek, Jihyun, Lee, Yu Ho, Jeong, Hye Yun, Lee, So-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Nephrology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565453/
https://www.ncbi.nlm.nih.gov/pubmed/37448292
http://dx.doi.org/10.23876/j.krcp.22.233
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author Baek, Jihyun
Lee, Yu Ho
Jeong, Hye Yun
Lee, So-Young
author_facet Baek, Jihyun
Lee, Yu Ho
Jeong, Hye Yun
Lee, So-Young
author_sort Baek, Jihyun
collection PubMed
description Most eukaryotic cells have mitochondrial networks that can change in shape, distribution, and size depending on cellular metabolic demands and environments. Mitochondrial quality control is critical for various mitochondrial functions including energy production, redox homeostasis, intracellular calcium handling, cell differentiation, proliferation, and cell death. Quality control mechanisms within mitochondria consist of antioxidant defenses, protein quality control, DNA damage repair systems, mitochondrial fusion and fission, mitophagy, and mitochondrial biogenesis. Defects in mitochondrial quality control and disruption of mitochondrial homeostasis are common characteristics of various kidney cell types under hyperglycemic conditions. Such defects contribute to diabetes-induced pathologies in renal tubular cells, podocytes, endothelial cells, and immune cells. In this review, we focus on the roles of mitochondrial quality control in diabetic kidney disease pathogenesis and discuss current research evidence and future directions.
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spelling pubmed-105654532023-10-12 Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease Baek, Jihyun Lee, Yu Ho Jeong, Hye Yun Lee, So-Young Kidney Res Clin Pract Review Article Most eukaryotic cells have mitochondrial networks that can change in shape, distribution, and size depending on cellular metabolic demands and environments. Mitochondrial quality control is critical for various mitochondrial functions including energy production, redox homeostasis, intracellular calcium handling, cell differentiation, proliferation, and cell death. Quality control mechanisms within mitochondria consist of antioxidant defenses, protein quality control, DNA damage repair systems, mitochondrial fusion and fission, mitophagy, and mitochondrial biogenesis. Defects in mitochondrial quality control and disruption of mitochondrial homeostasis are common characteristics of various kidney cell types under hyperglycemic conditions. Such defects contribute to diabetes-induced pathologies in renal tubular cells, podocytes, endothelial cells, and immune cells. In this review, we focus on the roles of mitochondrial quality control in diabetic kidney disease pathogenesis and discuss current research evidence and future directions. The Korean Society of Nephrology 2023-09 2023-05-22 /pmc/articles/PMC10565453/ /pubmed/37448292 http://dx.doi.org/10.23876/j.krcp.22.233 Text en Copyright © 2023 The Korean Society of Nephrology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial and No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) which permits unrestricted non-commercial use, distribution of the material without any modifications, and reproduction in any medium, provided the original works properly cited.
spellingShingle Review Article
Baek, Jihyun
Lee, Yu Ho
Jeong, Hye Yun
Lee, So-Young
Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease
title Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease
title_full Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease
title_fullStr Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease
title_full_unstemmed Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease
title_short Mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease
title_sort mitochondrial quality control and its emerging role in the pathogenesis of diabetic kidney disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565453/
https://www.ncbi.nlm.nih.gov/pubmed/37448292
http://dx.doi.org/10.23876/j.krcp.22.233
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