Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa

Submerged cultivation of Hypomontagnella monticulosa MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in...

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Autores principales: Heinemann, Henrike, Becker, Kevin, Schrey, Hedda, Zeng, Haoxuan, Stadler, Marc, Cox, Russell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565555/
https://www.ncbi.nlm.nih.gov/pubmed/37829708
http://dx.doi.org/10.1039/d3ra06542a
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author Heinemann, Henrike
Becker, Kevin
Schrey, Hedda
Zeng, Haoxuan
Stadler, Marc
Cox, Russell J.
author_facet Heinemann, Henrike
Becker, Kevin
Schrey, Hedda
Zeng, Haoxuan
Stadler, Marc
Cox, Russell J.
author_sort Heinemann, Henrike
collection PubMed
description Submerged cultivation of Hypomontagnella monticulosa MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in comparison to the precursor sporothriolide suggesting a detoxification mechanism. However, moderate effects on biofilms of Candida albicans and Staphylococcus aureus were observed for sporothriolide and sporothioethers A and B at concentrations below their MICs.
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spelling pubmed-105655552023-10-12 Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa Heinemann, Henrike Becker, Kevin Schrey, Hedda Zeng, Haoxuan Stadler, Marc Cox, Russell J. RSC Adv Chemistry Submerged cultivation of Hypomontagnella monticulosa MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in comparison to the precursor sporothriolide suggesting a detoxification mechanism. However, moderate effects on biofilms of Candida albicans and Staphylococcus aureus were observed for sporothriolide and sporothioethers A and B at concentrations below their MICs. The Royal Society of Chemistry 2023-10-11 /pmc/articles/PMC10565555/ /pubmed/37829708 http://dx.doi.org/10.1039/d3ra06542a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Heinemann, Henrike
Becker, Kevin
Schrey, Hedda
Zeng, Haoxuan
Stadler, Marc
Cox, Russell J.
Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa
title Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa
title_full Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa
title_fullStr Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa
title_full_unstemmed Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa
title_short Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa
title_sort sporothioethers: deactivated alkyl citrates from the fungus hypomontagnella monticulosa
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565555/
https://www.ncbi.nlm.nih.gov/pubmed/37829708
http://dx.doi.org/10.1039/d3ra06542a
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