Cargando…

Combination of multiple omics techniques for a personalized therapy or treatment selection

Despite targeted therapies and immunotherapies have revolutionized the treatment of cancer patients, only a limited number of patients have long-term responses. Moreover, due to differences within cancer patients in the tumor mutational burden, composition of the tumor microenvironment as well as of...

Descripción completa

Detalles Bibliográficos
Autores principales: Massa, Chiara, Seliger, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565668/
https://www.ncbi.nlm.nih.gov/pubmed/37828984
http://dx.doi.org/10.3389/fimmu.2023.1258013
_version_ 1785118745425870848
author Massa, Chiara
Seliger, Barbara
author_facet Massa, Chiara
Seliger, Barbara
author_sort Massa, Chiara
collection PubMed
description Despite targeted therapies and immunotherapies have revolutionized the treatment of cancer patients, only a limited number of patients have long-term responses. Moreover, due to differences within cancer patients in the tumor mutational burden, composition of the tumor microenvironment as well as of the peripheral immune system and microbiome, and in the development of immune escape mechanisms, there is no “one fit all” therapy. Thus, the treatment of patients must be personalized based on the specific molecular, immunologic and/or metabolic landscape of their tumor. In order to identify for each patient the best possible therapy, different approaches should be employed and combined. These include (i) the use of predictive biomarkers identified on large cohorts of patients with the same tumor type and (ii) the evaluation of the individual tumor with “omics”-based analyses as well as its ex vivo characterization for susceptibility to different therapies.
format Online
Article
Text
id pubmed-10565668
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-105656682023-10-12 Combination of multiple omics techniques for a personalized therapy or treatment selection Massa, Chiara Seliger, Barbara Front Immunol Immunology Despite targeted therapies and immunotherapies have revolutionized the treatment of cancer patients, only a limited number of patients have long-term responses. Moreover, due to differences within cancer patients in the tumor mutational burden, composition of the tumor microenvironment as well as of the peripheral immune system and microbiome, and in the development of immune escape mechanisms, there is no “one fit all” therapy. Thus, the treatment of patients must be personalized based on the specific molecular, immunologic and/or metabolic landscape of their tumor. In order to identify for each patient the best possible therapy, different approaches should be employed and combined. These include (i) the use of predictive biomarkers identified on large cohorts of patients with the same tumor type and (ii) the evaluation of the individual tumor with “omics”-based analyses as well as its ex vivo characterization for susceptibility to different therapies. Frontiers Media S.A. 2023-09-27 /pmc/articles/PMC10565668/ /pubmed/37828984 http://dx.doi.org/10.3389/fimmu.2023.1258013 Text en Copyright © 2023 Massa and Seliger https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Massa, Chiara
Seliger, Barbara
Combination of multiple omics techniques for a personalized therapy or treatment selection
title Combination of multiple omics techniques for a personalized therapy or treatment selection
title_full Combination of multiple omics techniques for a personalized therapy or treatment selection
title_fullStr Combination of multiple omics techniques for a personalized therapy or treatment selection
title_full_unstemmed Combination of multiple omics techniques for a personalized therapy or treatment selection
title_short Combination of multiple omics techniques for a personalized therapy or treatment selection
title_sort combination of multiple omics techniques for a personalized therapy or treatment selection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565668/
https://www.ncbi.nlm.nih.gov/pubmed/37828984
http://dx.doi.org/10.3389/fimmu.2023.1258013
work_keys_str_mv AT massachiara combinationofmultipleomicstechniquesforapersonalizedtherapyortreatmentselection
AT seligerbarbara combinationofmultipleomicstechniquesforapersonalizedtherapyortreatmentselection