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Ber-EP4 staining patterns on basal cell carcinomas

OBJECTIVE: This article aimed to study two different parameters of basal cell carcinoma (BCC): First, to analyze the expression of antihuman epithelial antigen (Ber-EP4) on the primary and recurrent BCCs on the head, neck, and other body parts and second, to find Ber-EP4’s staining pattern and stain...

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Autor principal: Ozkanli, Seyma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565738/
https://www.ncbi.nlm.nih.gov/pubmed/37829747
http://dx.doi.org/10.14744/nci.2022.25675
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author Ozkanli, Seyma
author_facet Ozkanli, Seyma
author_sort Ozkanli, Seyma
collection PubMed
description OBJECTIVE: This article aimed to study two different parameters of basal cell carcinoma (BCC): First, to analyze the expression of antihuman epithelial antigen (Ber-EP4) on the primary and recurrent BCCs on the head, neck, and other body parts and second, to find Ber-EP4’s staining pattern and staining intensities correlation between histological type, demographic data, tumor, and its prognostic parameters. METHODS: We evaluated the Ber-EP4 staining patterns of 201 patients diagnosed with BCC. We analyzed the possible correlation between the tumor’s prognostic parameters and the Ber-EP4 staining intensity and its pattern (peripheral, superficial, or diffused). RESULTS: In 199 out of the 201 cases, staining was observed. Two cases were unstained. In 25.6% (n=51) of the cases with staining, the staining was weak, on the 25.6% (n=51), it was moderate, and on the 48.8% (n=97), it was severe. The staining pattern was 31.2% (n=62) peripheral, 4.0% (n=8) superficial, 54.7% (n=109) diffuse, and 10.1% (n=20) peripheral and superficial. CONCLUSION: Ber-EP4 is the only antibody commonly used for BCC diagnosis; the existence of different staining intensities and patterns in BCC tumor cells in routine dermatopathology practice limit the pathologists. The studies investigating Ber-EP4 staining in BCCs were conducted with very small numbers of cases. In these studies, even the presence of staining in the focal area was considered to be a positive acceptance criterion; the staining intensity and pattern were not evaluated. Therefore, our study is the first study with a high number of cases and the first to include an evaluation of Ber-EP4 staining’s intensity and localization.
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spelling pubmed-105657382023-10-12 Ber-EP4 staining patterns on basal cell carcinomas Ozkanli, Seyma North Clin Istanb Original Article OBJECTIVE: This article aimed to study two different parameters of basal cell carcinoma (BCC): First, to analyze the expression of antihuman epithelial antigen (Ber-EP4) on the primary and recurrent BCCs on the head, neck, and other body parts and second, to find Ber-EP4’s staining pattern and staining intensities correlation between histological type, demographic data, tumor, and its prognostic parameters. METHODS: We evaluated the Ber-EP4 staining patterns of 201 patients diagnosed with BCC. We analyzed the possible correlation between the tumor’s prognostic parameters and the Ber-EP4 staining intensity and its pattern (peripheral, superficial, or diffused). RESULTS: In 199 out of the 201 cases, staining was observed. Two cases were unstained. In 25.6% (n=51) of the cases with staining, the staining was weak, on the 25.6% (n=51), it was moderate, and on the 48.8% (n=97), it was severe. The staining pattern was 31.2% (n=62) peripheral, 4.0% (n=8) superficial, 54.7% (n=109) diffuse, and 10.1% (n=20) peripheral and superficial. CONCLUSION: Ber-EP4 is the only antibody commonly used for BCC diagnosis; the existence of different staining intensities and patterns in BCC tumor cells in routine dermatopathology practice limit the pathologists. The studies investigating Ber-EP4 staining in BCCs were conducted with very small numbers of cases. In these studies, even the presence of staining in the focal area was considered to be a positive acceptance criterion; the staining intensity and pattern were not evaluated. Therefore, our study is the first study with a high number of cases and the first to include an evaluation of Ber-EP4 staining’s intensity and localization. Kare Publishing 2023-08-27 /pmc/articles/PMC10565738/ /pubmed/37829747 http://dx.doi.org/10.14744/nci.2022.25675 Text en © Copyright 2023 by Istanbul Provincial Directorate of Health https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Original Article
Ozkanli, Seyma
Ber-EP4 staining patterns on basal cell carcinomas
title Ber-EP4 staining patterns on basal cell carcinomas
title_full Ber-EP4 staining patterns on basal cell carcinomas
title_fullStr Ber-EP4 staining patterns on basal cell carcinomas
title_full_unstemmed Ber-EP4 staining patterns on basal cell carcinomas
title_short Ber-EP4 staining patterns on basal cell carcinomas
title_sort ber-ep4 staining patterns on basal cell carcinomas
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565738/
https://www.ncbi.nlm.nih.gov/pubmed/37829747
http://dx.doi.org/10.14744/nci.2022.25675
work_keys_str_mv AT ozkanliseyma berep4stainingpatternsonbasalcellcarcinomas