Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction

Mutations of the transcription factor FoxP3 in patients with “IPEX” (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) disrupt regulatory T cells (Treg), causing an array of multiorgan autoimmunity. To understand the functional impact of mutations across FoxP3 domains, withou...

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Detalles Bibliográficos
Autores principales: Leon, Juliette, Chowdhary, Kaitavjeet, Zhang, Wenxiang, Ramirez, Ricardo N., André, Isabelle, Hur, Sun, Mathis, Diane, Benoist, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565790/
https://www.ncbi.nlm.nih.gov/pubmed/37605532
http://dx.doi.org/10.1016/j.celrep.2023.113018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565790/
https://www.ncbi.nlm.nih.gov/pubmed/37605532
http://dx.doi.org/10.1016/j.celrep.2023.113018

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