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Glutathione and peroxisome redox homeostasis

Despite intensive research on peroxisome biochemistry, the role of glutathione in peroxisomal redox homeostasis has remained a matter of speculation for many years, and only recently has this issue started to be experimentally addressed. Here, we summarize and compare data from several organisms on...

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Detalles Bibliográficos
Autores principales: Ferreira, Maria J., Rodrigues, Tony A., Pedrosa, Ana G., Silva, Ana R., Vilarinho, Beatriz G., Francisco, Tânia, Azevedo, Jorge E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565873/
https://www.ncbi.nlm.nih.gov/pubmed/37804696
http://dx.doi.org/10.1016/j.redox.2023.102917
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author Ferreira, Maria J.
Rodrigues, Tony A.
Pedrosa, Ana G.
Silva, Ana R.
Vilarinho, Beatriz G.
Francisco, Tânia
Azevedo, Jorge E.
author_facet Ferreira, Maria J.
Rodrigues, Tony A.
Pedrosa, Ana G.
Silva, Ana R.
Vilarinho, Beatriz G.
Francisco, Tânia
Azevedo, Jorge E.
author_sort Ferreira, Maria J.
collection PubMed
description Despite intensive research on peroxisome biochemistry, the role of glutathione in peroxisomal redox homeostasis has remained a matter of speculation for many years, and only recently has this issue started to be experimentally addressed. Here, we summarize and compare data from several organisms on the peroxisome-glutathione topic. It is clear from this comparison that the repertoire of glutathione-utilizing enzymes in peroxisomes of different organisms varies widely. In addition, the available data suggest that the kinetic connectivity between the cytosolic and peroxisomal pools of glutathione may also be different in different organisms, with some possessing a peroxisomal membrane that is promptly permeable to glutathione whereas in others this may not be the case. However, regardless of the differences, the picture that emerges from all these data is that glutathione is a crucial component of the antioxidative system that operates inside peroxisomes in all organisms.
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spelling pubmed-105658732023-10-12 Glutathione and peroxisome redox homeostasis Ferreira, Maria J. Rodrigues, Tony A. Pedrosa, Ana G. Silva, Ana R. Vilarinho, Beatriz G. Francisco, Tânia Azevedo, Jorge E. Redox Biol Review Article Despite intensive research on peroxisome biochemistry, the role of glutathione in peroxisomal redox homeostasis has remained a matter of speculation for many years, and only recently has this issue started to be experimentally addressed. Here, we summarize and compare data from several organisms on the peroxisome-glutathione topic. It is clear from this comparison that the repertoire of glutathione-utilizing enzymes in peroxisomes of different organisms varies widely. In addition, the available data suggest that the kinetic connectivity between the cytosolic and peroxisomal pools of glutathione may also be different in different organisms, with some possessing a peroxisomal membrane that is promptly permeable to glutathione whereas in others this may not be the case. However, regardless of the differences, the picture that emerges from all these data is that glutathione is a crucial component of the antioxidative system that operates inside peroxisomes in all organisms. Elsevier 2023-10-04 /pmc/articles/PMC10565873/ /pubmed/37804696 http://dx.doi.org/10.1016/j.redox.2023.102917 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Ferreira, Maria J.
Rodrigues, Tony A.
Pedrosa, Ana G.
Silva, Ana R.
Vilarinho, Beatriz G.
Francisco, Tânia
Azevedo, Jorge E.
Glutathione and peroxisome redox homeostasis
title Glutathione and peroxisome redox homeostasis
title_full Glutathione and peroxisome redox homeostasis
title_fullStr Glutathione and peroxisome redox homeostasis
title_full_unstemmed Glutathione and peroxisome redox homeostasis
title_short Glutathione and peroxisome redox homeostasis
title_sort glutathione and peroxisome redox homeostasis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565873/
https://www.ncbi.nlm.nih.gov/pubmed/37804696
http://dx.doi.org/10.1016/j.redox.2023.102917
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