Management and prevention of corneal graft rejection

The management of an episode of corneal graft rejection (CGR) is primarily by corticosteroids. Immunomodulators are useful for long-term immunosuppression and in dealing with cases of high-risk (HR) corneal grafts. The classical signs of CGR following penetrating keratoplasty (PKP) include rejection...

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Autores principales: Mandal, Sohini, Maharana, Prafulla K, Kaweri, Luci, Asif, Mohamed I, Nagpal, Ritu, Sharma, Namrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565940/
https://www.ncbi.nlm.nih.gov/pubmed/37602601
http://dx.doi.org/10.4103/IJO.IJO_228_23
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author Mandal, Sohini
Maharana, Prafulla K
Kaweri, Luci
Asif, Mohamed I
Nagpal, Ritu
Sharma, Namrata
author_facet Mandal, Sohini
Maharana, Prafulla K
Kaweri, Luci
Asif, Mohamed I
Nagpal, Ritu
Sharma, Namrata
author_sort Mandal, Sohini
collection PubMed
description The management of an episode of corneal graft rejection (CGR) is primarily by corticosteroids. Immunomodulators are useful for long-term immunosuppression and in dealing with cases of high-risk (HR) corneal grafts. The classical signs of CGR following penetrating keratoplasty (PKP) include rejection line, anterior chamber (AC) reaction, and graft edema. However, these signs may be absent or subtle in cases of endothelial keratoplasty (EK). Prevention of an episode of graft rejection is of utmost importance as it can reduce the need for donor cornea significantly. In our previous article (IJO_2866_22), we had discussed about the immunopathogenesis of CGR. In this review article, we aim to discuss the various clinical aspects and management of CGR.
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spelling pubmed-105659402023-10-12 Management and prevention of corneal graft rejection Mandal, Sohini Maharana, Prafulla K Kaweri, Luci Asif, Mohamed I Nagpal, Ritu Sharma, Namrata Indian J Ophthalmol Review Article The management of an episode of corneal graft rejection (CGR) is primarily by corticosteroids. Immunomodulators are useful for long-term immunosuppression and in dealing with cases of high-risk (HR) corneal grafts. The classical signs of CGR following penetrating keratoplasty (PKP) include rejection line, anterior chamber (AC) reaction, and graft edema. However, these signs may be absent or subtle in cases of endothelial keratoplasty (EK). Prevention of an episode of graft rejection is of utmost importance as it can reduce the need for donor cornea significantly. In our previous article (IJO_2866_22), we had discussed about the immunopathogenesis of CGR. In this review article, we aim to discuss the various clinical aspects and management of CGR. Wolters Kluwer - Medknow 2023-09 2023-08-21 /pmc/articles/PMC10565940/ /pubmed/37602601 http://dx.doi.org/10.4103/IJO.IJO_228_23 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Mandal, Sohini
Maharana, Prafulla K
Kaweri, Luci
Asif, Mohamed I
Nagpal, Ritu
Sharma, Namrata
Management and prevention of corneal graft rejection
title Management and prevention of corneal graft rejection
title_full Management and prevention of corneal graft rejection
title_fullStr Management and prevention of corneal graft rejection
title_full_unstemmed Management and prevention of corneal graft rejection
title_short Management and prevention of corneal graft rejection
title_sort management and prevention of corneal graft rejection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565940/
https://www.ncbi.nlm.nih.gov/pubmed/37602601
http://dx.doi.org/10.4103/IJO.IJO_228_23
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