Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?

INTRODUCTION: The first predominant clinical symptoms of dementia with Lewy bodies (DLB) are highly variable; however, the prognosis based on initial predominant symptoms remains poorly understood. METHODS: Multicenter retrospective study in 4 French expert neurological centers. Patients were catego...

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Autores principales: Aveneau, Clément, Wallon, David, Degos, Bertrand, Obadia, Alexandre, Hourregue, Claire, Benisty, Sarah, Garcin, Béatrice, Dumurgier, Julien, Paquet, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565988/
https://www.ncbi.nlm.nih.gov/pubmed/37821973
http://dx.doi.org/10.1186/s13195-023-01305-7
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author Aveneau, Clément
Wallon, David
Degos, Bertrand
Obadia, Alexandre
Hourregue, Claire
Benisty, Sarah
Garcin, Béatrice
Dumurgier, Julien
Paquet, Claire
author_facet Aveneau, Clément
Wallon, David
Degos, Bertrand
Obadia, Alexandre
Hourregue, Claire
Benisty, Sarah
Garcin, Béatrice
Dumurgier, Julien
Paquet, Claire
author_sort Aveneau, Clément
collection PubMed
description INTRODUCTION: The first predominant clinical symptoms of dementia with Lewy bodies (DLB) are highly variable; however, the prognosis based on initial predominant symptoms remains poorly understood. METHODS: Multicenter retrospective study in 4 French expert neurological centers. Patients were categorized in 3 groups according to their first more predominant symptoms: cognitive, psychiatric, or motor. RESULTS: Analysis of 310 DLB patients. The mean age was 73.5 years old (SD 7.5) including 32.3% of women. The mean follow-up was 7.25 years (SD 3.6). We observed that the full clinical picture was more frequent in the motor group than in the cognitive group (p = 0.01); male gender and age at onset were associated with a significant excess risk of instantaneous mortality (p = 0.01). CONCLUSION: Initial symptoms may affect the clinical course of patients, but no significant difference in mortality was observed.
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spelling pubmed-105659882023-10-12 Is the clinical phenotype impact the prognosis in dementia with Lewy bodies? Aveneau, Clément Wallon, David Degos, Bertrand Obadia, Alexandre Hourregue, Claire Benisty, Sarah Garcin, Béatrice Dumurgier, Julien Paquet, Claire Alzheimers Res Ther Research INTRODUCTION: The first predominant clinical symptoms of dementia with Lewy bodies (DLB) are highly variable; however, the prognosis based on initial predominant symptoms remains poorly understood. METHODS: Multicenter retrospective study in 4 French expert neurological centers. Patients were categorized in 3 groups according to their first more predominant symptoms: cognitive, psychiatric, or motor. RESULTS: Analysis of 310 DLB patients. The mean age was 73.5 years old (SD 7.5) including 32.3% of women. The mean follow-up was 7.25 years (SD 3.6). We observed that the full clinical picture was more frequent in the motor group than in the cognitive group (p = 0.01); male gender and age at onset were associated with a significant excess risk of instantaneous mortality (p = 0.01). CONCLUSION: Initial symptoms may affect the clinical course of patients, but no significant difference in mortality was observed. BioMed Central 2023-10-11 /pmc/articles/PMC10565988/ /pubmed/37821973 http://dx.doi.org/10.1186/s13195-023-01305-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Aveneau, Clément
Wallon, David
Degos, Bertrand
Obadia, Alexandre
Hourregue, Claire
Benisty, Sarah
Garcin, Béatrice
Dumurgier, Julien
Paquet, Claire
Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
title Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
title_full Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
title_fullStr Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
title_full_unstemmed Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
title_short Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
title_sort is the clinical phenotype impact the prognosis in dementia with lewy bodies?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565988/
https://www.ncbi.nlm.nih.gov/pubmed/37821973
http://dx.doi.org/10.1186/s13195-023-01305-7
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