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Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging

The insulin-degrading enzyme (IDE) is an evolutionarily conserved zinc-dependent metallopeptidase highly expressed in the brain, where its specific functions remain poorly understood. Besides insulin, IDE is able to cleave many substrates in vitro, including amyloid beta peptides, making this enzyme...

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Detalles Bibliográficos
Autores principales:	Corraliza-Gomez, Miriam, Bermejo, Teresa, Lilue, Jingtao, Rodriguez-Iglesias, Noelia, Valero, Jorge, Cozar-Castellano, Irene, Arranz, Eduardo, Sanchez, Diego, Ganfornina, Maria Dolores
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566021/ https://www.ncbi.nlm.nih.gov/pubmed/37817156 http://dx.doi.org/10.1186/s12974-023-02914-7

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