Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity

OBJECTIVES: To study clinical disease outcomes in both human and animal models to understand the pathogenicity of omicron compared to the delta variant. METHODS: In this cross-sectional observational study, clinical outcomes of adults who tested positive at 2 testing centres in Delhi National Capita...

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Autores principales: Thiruvengadam, Ramachandran, Rizvi, Zaigham Abbas, Raghavan, Sreevatsan, Murugesan, Deepika Rathna, Gosain, Mudita, Dandotiya, Jyotsna, Ayushi, Samal, Sweety, Pandey, Anil K., Wadhwa, Nitya, Bhatnagar, Shinjini, Awasthi, Amit, Garg, Pramod Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566023/
https://www.ncbi.nlm.nih.gov/pubmed/37821945
http://dx.doi.org/10.1186/s40001-023-01373-3
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author Thiruvengadam, Ramachandran
Rizvi, Zaigham Abbas
Raghavan, Sreevatsan
Murugesan, Deepika Rathna
Gosain, Mudita
Dandotiya, Jyotsna
Ayushi
Samal, Sweety
Pandey, Anil K.
Wadhwa, Nitya
Bhatnagar, Shinjini
Awasthi, Amit
Garg, Pramod Kumar
author_facet Thiruvengadam, Ramachandran
Rizvi, Zaigham Abbas
Raghavan, Sreevatsan
Murugesan, Deepika Rathna
Gosain, Mudita
Dandotiya, Jyotsna
Ayushi
Samal, Sweety
Pandey, Anil K.
Wadhwa, Nitya
Bhatnagar, Shinjini
Awasthi, Amit
Garg, Pramod Kumar
author_sort Thiruvengadam, Ramachandran
collection PubMed
description OBJECTIVES: To study clinical disease outcomes in both human and animal models to understand the pathogenicity of omicron compared to the delta variant. METHODS: In this cross-sectional observational study, clinical outcomes of adults who tested positive at 2 testing centres in Delhi National Capital Region between January 2022 and March 2022 (omicron-infected; N = 2998) were compared to a similar geographical cohort (delta-infected; N = 3292). In addition, disease course and outcomes were studied in SARS-CoV-2-infected golden Syrian hamsters and K-18 humanized ACE2 transgenic mice. RESULTS: Omicron variant infection was associated with a milder clinical course [83% (95% CI 61, 94) reduced risk of severity compared against delta] adjusting for vaccination, age, sex, prior infection and occupational risk. This correlated with lower disease index and vir comparing omicron with other variants in animal models. CONCLUSIONS: Infections caused by the omicron variant were milder compared to those caused by the delta variant independent of previous immunity.
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spelling pubmed-105660232023-10-12 Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity Thiruvengadam, Ramachandran Rizvi, Zaigham Abbas Raghavan, Sreevatsan Murugesan, Deepika Rathna Gosain, Mudita Dandotiya, Jyotsna Ayushi Samal, Sweety Pandey, Anil K. Wadhwa, Nitya Bhatnagar, Shinjini Awasthi, Amit Garg, Pramod Kumar Eur J Med Res Research OBJECTIVES: To study clinical disease outcomes in both human and animal models to understand the pathogenicity of omicron compared to the delta variant. METHODS: In this cross-sectional observational study, clinical outcomes of adults who tested positive at 2 testing centres in Delhi National Capital Region between January 2022 and March 2022 (omicron-infected; N = 2998) were compared to a similar geographical cohort (delta-infected; N = 3292). In addition, disease course and outcomes were studied in SARS-CoV-2-infected golden Syrian hamsters and K-18 humanized ACE2 transgenic mice. RESULTS: Omicron variant infection was associated with a milder clinical course [83% (95% CI 61, 94) reduced risk of severity compared against delta] adjusting for vaccination, age, sex, prior infection and occupational risk. This correlated with lower disease index and vir comparing omicron with other variants in animal models. CONCLUSIONS: Infections caused by the omicron variant were milder compared to those caused by the delta variant independent of previous immunity. BioMed Central 2023-10-11 /pmc/articles/PMC10566023/ /pubmed/37821945 http://dx.doi.org/10.1186/s40001-023-01373-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Thiruvengadam, Ramachandran
Rizvi, Zaigham Abbas
Raghavan, Sreevatsan
Murugesan, Deepika Rathna
Gosain, Mudita
Dandotiya, Jyotsna
Ayushi
Samal, Sweety
Pandey, Anil K.
Wadhwa, Nitya
Bhatnagar, Shinjini
Awasthi, Amit
Garg, Pramod Kumar
Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity
title Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity
title_full Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity
title_fullStr Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity
title_full_unstemmed Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity
title_short Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity
title_sort clinical and experimental evidence suggest omicron variant of sars-cov-2 is inherently less pathogenic than delta variant independent of previous immunity
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566023/
https://www.ncbi.nlm.nih.gov/pubmed/37821945
http://dx.doi.org/10.1186/s40001-023-01373-3
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