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Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72
BACKGROUND: The first crystal structure of the active μ opioid receptor (μOR) exhibited several unexplained features. The ligand BU72 exhibited many extreme deviations from ideal geometry, along with unexplained electron density. I previously showed that inverting the benzylic configuration resolved...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566028/ https://www.ncbi.nlm.nih.gov/pubmed/37817141 http://dx.doi.org/10.1186/s12915-023-01689-w |