RFC2 promotes aerobic glycolysis and progression of colorectal cancer

BACKGROUND: Replication factor C subunit 2 (RFC2) participates in the growth and metastasis of various malignancies. Our study investigated the roles of RFC2 in colorectal cancer (CRC). RESULTS: RFC2 expression was upregulated in CRC tissues and cells. High RFC2 expression was associated with poor p...

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Detalles Bibliográficos
Autores principales: Lou, Fuchen, Zhang, Mingbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566032/
https://www.ncbi.nlm.nih.gov/pubmed/37821801
http://dx.doi.org/10.1186/s12876-023-02984-0
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author Lou, Fuchen
Zhang, Mingbao
author_facet Lou, Fuchen
Zhang, Mingbao
author_sort Lou, Fuchen
collection PubMed
description BACKGROUND: Replication factor C subunit 2 (RFC2) participates in the growth and metastasis of various malignancies. Our study investigated the roles of RFC2 in colorectal cancer (CRC). RESULTS: RFC2 expression was upregulated in CRC tissues and cells. High RFC2 expression was associated with poor prognosis. Knockdown RFC2 inhibited proliferation, induced apoptosis, and suppressed migration and invasion of CRC cells. CREB5 was a transcription factor of RFC2, and CREB5 knockdown suppressed RFC2 expression. Furthermore, RFC2 promoted aerobic glycolysis and MET/PI3K/AKT/mTOR pathway. CONCLUSION: RFC2 promoted the progression of CRC cells via activating aerobic glycolysis and the MET/PI3K/AKT/mTOR pathway. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-023-02984-0.
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spelling pubmed-105660322023-10-12 RFC2 promotes aerobic glycolysis and progression of colorectal cancer Lou, Fuchen Zhang, Mingbao BMC Gastroenterol Research BACKGROUND: Replication factor C subunit 2 (RFC2) participates in the growth and metastasis of various malignancies. Our study investigated the roles of RFC2 in colorectal cancer (CRC). RESULTS: RFC2 expression was upregulated in CRC tissues and cells. High RFC2 expression was associated with poor prognosis. Knockdown RFC2 inhibited proliferation, induced apoptosis, and suppressed migration and invasion of CRC cells. CREB5 was a transcription factor of RFC2, and CREB5 knockdown suppressed RFC2 expression. Furthermore, RFC2 promoted aerobic glycolysis and MET/PI3K/AKT/mTOR pathway. CONCLUSION: RFC2 promoted the progression of CRC cells via activating aerobic glycolysis and the MET/PI3K/AKT/mTOR pathway. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-023-02984-0. BioMed Central 2023-10-11 /pmc/articles/PMC10566032/ /pubmed/37821801 http://dx.doi.org/10.1186/s12876-023-02984-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lou, Fuchen
Zhang, Mingbao
RFC2 promotes aerobic glycolysis and progression of colorectal cancer
title RFC2 promotes aerobic glycolysis and progression of colorectal cancer
title_full RFC2 promotes aerobic glycolysis and progression of colorectal cancer
title_fullStr RFC2 promotes aerobic glycolysis and progression of colorectal cancer
title_full_unstemmed RFC2 promotes aerobic glycolysis and progression of colorectal cancer
title_short RFC2 promotes aerobic glycolysis and progression of colorectal cancer
title_sort rfc2 promotes aerobic glycolysis and progression of colorectal cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566032/
https://www.ncbi.nlm.nih.gov/pubmed/37821801
http://dx.doi.org/10.1186/s12876-023-02984-0
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