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Insights into vascular physiology from sleep photoplethysmography
STUDY OBJECTIVES: Photoplethysmography (PPG) in consumer sleep trackers is now widely available and used to assess heart rate variability (HRV) for sleep staging. However, PPG waveform changes during sleep can also inform about vascular elasticity in healthy persons who constitute a majority of user...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566244/ https://www.ncbi.nlm.nih.gov/pubmed/37379483 http://dx.doi.org/10.1093/sleep/zsad172 |
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author | Yilmaz, Gizem Ong, Ju Lynn Ling, Lieng-Hsi Chee, Michael W L |
author_facet | Yilmaz, Gizem Ong, Ju Lynn Ling, Lieng-Hsi Chee, Michael W L |
author_sort | Yilmaz, Gizem |
collection | PubMed |
description | STUDY OBJECTIVES: Photoplethysmography (PPG) in consumer sleep trackers is now widely available and used to assess heart rate variability (HRV) for sleep staging. However, PPG waveform changes during sleep can also inform about vascular elasticity in healthy persons who constitute a majority of users. To assess its potential value, we traced the evolution of PPG pulse waveform during sleep alongside measurements of HRV and blood pressure (BP). METHODS: Seventy-eight healthy adults (50% male, median [IQR range] age: 29.5 [23.0, 43.8]) underwent overnight polysomnography (PSG) with fingertip PPG, ambulatory blood pressure monitoring, and electrocardiography (ECG). Selected PPG features that reflect arterial stiffness: systolic to diastolic distance (∆T_norm), normalized rising slope (Rslope) and normalized reflection index (RI) were derived using a custom-built algorithm. Pulse arrival time (PAT) was calculated using ECG and PPG signals. The effect of sleep stage on these measures of arterial elasticity and how this pattern of sleep stage evolution differed with participant age were investigated. RESULTS: BP, heart rate (HR) and PAT were reduced with deeper non-REM sleep but these changes were unaffected by the age range tested. After adjusting for lowered HR, ∆T_norm, Rslope, and RI showed significant effects of sleep stage, whereby deeper sleep was associated with lower arterial stiffness. Age was significantly correlated with the amount of sleep-related change in ∆T_norm, Rslope, and RI, and remained a significant predictor of RI after adjustment for sex, body mass index, office BP, and sleep efficiency. CONCLUSIONS: The current findings indicate that the magnitude of sleep-related change in PPG waveform can provide useful information about vascular elasticity and age effects on this in healthy adults. |
format | Online Article Text |
id | pubmed-10566244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105662442023-10-12 Insights into vascular physiology from sleep photoplethysmography Yilmaz, Gizem Ong, Ju Lynn Ling, Lieng-Hsi Chee, Michael W L Sleep Sleep, Health, and Disease STUDY OBJECTIVES: Photoplethysmography (PPG) in consumer sleep trackers is now widely available and used to assess heart rate variability (HRV) for sleep staging. However, PPG waveform changes during sleep can also inform about vascular elasticity in healthy persons who constitute a majority of users. To assess its potential value, we traced the evolution of PPG pulse waveform during sleep alongside measurements of HRV and blood pressure (BP). METHODS: Seventy-eight healthy adults (50% male, median [IQR range] age: 29.5 [23.0, 43.8]) underwent overnight polysomnography (PSG) with fingertip PPG, ambulatory blood pressure monitoring, and electrocardiography (ECG). Selected PPG features that reflect arterial stiffness: systolic to diastolic distance (∆T_norm), normalized rising slope (Rslope) and normalized reflection index (RI) were derived using a custom-built algorithm. Pulse arrival time (PAT) was calculated using ECG and PPG signals. The effect of sleep stage on these measures of arterial elasticity and how this pattern of sleep stage evolution differed with participant age were investigated. RESULTS: BP, heart rate (HR) and PAT were reduced with deeper non-REM sleep but these changes were unaffected by the age range tested. After adjusting for lowered HR, ∆T_norm, Rslope, and RI showed significant effects of sleep stage, whereby deeper sleep was associated with lower arterial stiffness. Age was significantly correlated with the amount of sleep-related change in ∆T_norm, Rslope, and RI, and remained a significant predictor of RI after adjustment for sex, body mass index, office BP, and sleep efficiency. CONCLUSIONS: The current findings indicate that the magnitude of sleep-related change in PPG waveform can provide useful information about vascular elasticity and age effects on this in healthy adults. Oxford University Press 2023-06-28 /pmc/articles/PMC10566244/ /pubmed/37379483 http://dx.doi.org/10.1093/sleep/zsad172 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Sleep, Health, and Disease Yilmaz, Gizem Ong, Ju Lynn Ling, Lieng-Hsi Chee, Michael W L Insights into vascular physiology from sleep photoplethysmography |
title | Insights into vascular physiology from sleep photoplethysmography |
title_full | Insights into vascular physiology from sleep photoplethysmography |
title_fullStr | Insights into vascular physiology from sleep photoplethysmography |
title_full_unstemmed | Insights into vascular physiology from sleep photoplethysmography |
title_short | Insights into vascular physiology from sleep photoplethysmography |
title_sort | insights into vascular physiology from sleep photoplethysmography |
topic | Sleep, Health, and Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566244/ https://www.ncbi.nlm.nih.gov/pubmed/37379483 http://dx.doi.org/10.1093/sleep/zsad172 |
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