Supramolecular assembly of pyrene–DNA conjugates: influence of pyrene substitution pattern and implications for artificial LHCs

The supramolecular self-assembly of pyrene–DNA conjugates into nanostructures is presented. DNA functionalized with different types of pyrene isomers at the 3′-end self-assemble into nano-objects. The shape of the nanostructures is influenced by the type of pyrene isomer appended to the DNA. Multila...

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Detalles Bibliográficos
Autores principales: Thiede, Jan, Rothenbühler, Simon, Iacovache, Ioan, Langenegger, Simon M., Zuber, Benoît, Häner, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566252/
https://www.ncbi.nlm.nih.gov/pubmed/37750811
http://dx.doi.org/10.1039/d3ob01375h
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author Thiede, Jan
Rothenbühler, Simon
Iacovache, Ioan
Langenegger, Simon M.
Zuber, Benoît
Häner, Robert
author_facet Thiede, Jan
Rothenbühler, Simon
Iacovache, Ioan
Langenegger, Simon M.
Zuber, Benoît
Häner, Robert
author_sort Thiede, Jan
collection PubMed
description The supramolecular self-assembly of pyrene–DNA conjugates into nanostructures is presented. DNA functionalized with different types of pyrene isomers at the 3′-end self-assemble into nano-objects. The shape of the nanostructures is influenced by the type of pyrene isomer appended to the DNA. Multilamellar vesicles are observed with the 1,6- and 1,8-isomers, whereas conjugates of the 2,7-isomer exclusively assemble into spherical nanoparticles. Self-assembled nano-spheres obtained with the 2,7-dialkynyl pyrene isomer were used for the construction of an artificial light-harvesting complex (LHC) in combination with Cy3 as the energy acceptor.
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spelling pubmed-105662522023-10-12 Supramolecular assembly of pyrene–DNA conjugates: influence of pyrene substitution pattern and implications for artificial LHCs Thiede, Jan Rothenbühler, Simon Iacovache, Ioan Langenegger, Simon M. Zuber, Benoît Häner, Robert Org Biomol Chem Chemistry The supramolecular self-assembly of pyrene–DNA conjugates into nanostructures is presented. DNA functionalized with different types of pyrene isomers at the 3′-end self-assemble into nano-objects. The shape of the nanostructures is influenced by the type of pyrene isomer appended to the DNA. Multilamellar vesicles are observed with the 1,6- and 1,8-isomers, whereas conjugates of the 2,7-isomer exclusively assemble into spherical nanoparticles. Self-assembled nano-spheres obtained with the 2,7-dialkynyl pyrene isomer were used for the construction of an artificial light-harvesting complex (LHC) in combination with Cy3 as the energy acceptor. The Royal Society of Chemistry 2023-09-21 /pmc/articles/PMC10566252/ /pubmed/37750811 http://dx.doi.org/10.1039/d3ob01375h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Thiede, Jan
Rothenbühler, Simon
Iacovache, Ioan
Langenegger, Simon M.
Zuber, Benoît
Häner, Robert
Supramolecular assembly of pyrene–DNA conjugates: influence of pyrene substitution pattern and implications for artificial LHCs
title Supramolecular assembly of pyrene–DNA conjugates: influence of pyrene substitution pattern and implications for artificial LHCs
title_full Supramolecular assembly of pyrene–DNA conjugates: influence of pyrene substitution pattern and implications for artificial LHCs
title_fullStr Supramolecular assembly of pyrene–DNA conjugates: influence of pyrene substitution pattern and implications for artificial LHCs
title_full_unstemmed Supramolecular assembly of pyrene–DNA conjugates: influence of pyrene substitution pattern and implications for artificial LHCs
title_short Supramolecular assembly of pyrene–DNA conjugates: influence of pyrene substitution pattern and implications for artificial LHCs
title_sort supramolecular assembly of pyrene–dna conjugates: influence of pyrene substitution pattern and implications for artificial lhcs
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566252/
https://www.ncbi.nlm.nih.gov/pubmed/37750811
http://dx.doi.org/10.1039/d3ob01375h
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