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Clinical presentation of monkeypox in patients with different HIV serostatus – two cases from Bulgaria: A case report

Monkeypox is an emerging zoonosis that has been declared a public health threat due to its spread outside of endemic areas. We present two cases of monkeypox: one involving a 39-year-old male patient living with HIV on antiretroviral therapy with detectable viraemia and a low CD4 count, and another...

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Autores principales: Ivanov, Daniel Toshkov, Yancheva, Nina Stoyanova, Valkov, Trifon Kostadinov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566263/
https://www.ncbi.nlm.nih.gov/pubmed/37829352
http://dx.doi.org/10.1177/2050313X231204193
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author Ivanov, Daniel Toshkov
Yancheva, Nina Stoyanova
Valkov, Trifon Kostadinov
author_facet Ivanov, Daniel Toshkov
Yancheva, Nina Stoyanova
Valkov, Trifon Kostadinov
author_sort Ivanov, Daniel Toshkov
collection PubMed
description Monkeypox is an emerging zoonosis that has been declared a public health threat due to its spread outside of endemic areas. We present two cases of monkeypox: one involving a 39-year-old male patient living with HIV on antiretroviral therapy with detectable viraemia and a low CD4 count, and another involving a 44-year-old male, negative for HIV, who visited our Diagnostic and Consultative Unit with a new-onset skin rash. Both individuals identify as men who have sex with men and had travelled abroad before the disease onset. One patient was hospitalised, while the other was treated as an outpatient with follow-up care. Both cases were managed conservatively due to the unavailability of tecovirimat in Bulgaria. We emphasise the importance of recognising and diagnosing monkeypox and the significance of HIV screening, as monkeypox could be considered an AIDS-defining condition in people living with HIV. Maintaining a high level of suspicion for new cases is essential, as instances of monkeypox continue to be reported in non-endemic countries.
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spelling pubmed-105662632023-10-12 Clinical presentation of monkeypox in patients with different HIV serostatus – two cases from Bulgaria: A case report Ivanov, Daniel Toshkov Yancheva, Nina Stoyanova Valkov, Trifon Kostadinov SAGE Open Med Case Rep Case Report Monkeypox is an emerging zoonosis that has been declared a public health threat due to its spread outside of endemic areas. We present two cases of monkeypox: one involving a 39-year-old male patient living with HIV on antiretroviral therapy with detectable viraemia and a low CD4 count, and another involving a 44-year-old male, negative for HIV, who visited our Diagnostic and Consultative Unit with a new-onset skin rash. Both individuals identify as men who have sex with men and had travelled abroad before the disease onset. One patient was hospitalised, while the other was treated as an outpatient with follow-up care. Both cases were managed conservatively due to the unavailability of tecovirimat in Bulgaria. We emphasise the importance of recognising and diagnosing monkeypox and the significance of HIV screening, as monkeypox could be considered an AIDS-defining condition in people living with HIV. Maintaining a high level of suspicion for new cases is essential, as instances of monkeypox continue to be reported in non-endemic countries. SAGE Publications 2023-10-10 /pmc/articles/PMC10566263/ /pubmed/37829352 http://dx.doi.org/10.1177/2050313X231204193 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Ivanov, Daniel Toshkov
Yancheva, Nina Stoyanova
Valkov, Trifon Kostadinov
Clinical presentation of monkeypox in patients with different HIV serostatus – two cases from Bulgaria: A case report
title Clinical presentation of monkeypox in patients with different HIV serostatus – two cases from Bulgaria: A case report
title_full Clinical presentation of monkeypox in patients with different HIV serostatus – two cases from Bulgaria: A case report
title_fullStr Clinical presentation of monkeypox in patients with different HIV serostatus – two cases from Bulgaria: A case report
title_full_unstemmed Clinical presentation of monkeypox in patients with different HIV serostatus – two cases from Bulgaria: A case report
title_short Clinical presentation of monkeypox in patients with different HIV serostatus – two cases from Bulgaria: A case report
title_sort clinical presentation of monkeypox in patients with different hiv serostatus – two cases from bulgaria: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566263/
https://www.ncbi.nlm.nih.gov/pubmed/37829352
http://dx.doi.org/10.1177/2050313X231204193
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