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The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review

A significant number of cancer-related deaths are recorded globally each year, despite attempts to cure this illness. Medical science is working to develop new medication therapies as well as to find ways to identify this illness as early as possible, even using noninvasive techniques. Early detecti...

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Autores principales: Jafari, Ali, Karimabadi, Keyvan, Rahimi, Aso, Rostaminasab, Gelavizh, Khazaei, Mozafar, Rezakhani, Leila, Ahmadi jouybari, Touraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566290/
https://www.ncbi.nlm.nih.gov/pubmed/37817634
http://dx.doi.org/10.1177/15330338231205999
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author Jafari, Ali
Karimabadi, Keyvan
Rahimi, Aso
Rostaminasab, Gelavizh
Khazaei, Mozafar
Rezakhani, Leila
Ahmadi jouybari, Touraj
author_facet Jafari, Ali
Karimabadi, Keyvan
Rahimi, Aso
Rostaminasab, Gelavizh
Khazaei, Mozafar
Rezakhani, Leila
Ahmadi jouybari, Touraj
author_sort Jafari, Ali
collection PubMed
description A significant number of cancer-related deaths are recorded globally each year, despite attempts to cure this illness. Medical science is working to develop new medication therapies as well as to find ways to identify this illness as early as possible, even using noninvasive techniques. Early detection of cancer can greatly aid its treatment. Studies into cancer diagnosis and therapy have recently shifted their focus to exosome (EXO) biomarkers, which comprise numerous RNA and proteins. EXOs are minuscule goblet vesicles that have a width of 30 to 140 nm and are released by a variety of cells, including immune, stem, and tumor cells, as well as bodily fluids. According to a growing body of research, EXOs, and cancer appear to be related. EXOs from tumors play a role in the genetic information transfer between tumor and basal cells, which controls angiogenesis and fosters tumor development and spread. To identify malignant activities early on, microRNAs (miRNAs) from cancers can be extracted from circulatory system EXOs. Specific markers can be used to identify cancer-derived EXOs containing miRNAs, which may be more reliable and precise for early detection. Conventional solid biopsy has become increasingly limited as precision and personalized medicine has advanced, while liquid biopsy offers a viable platform for noninvasive diagnosis and prognosis. Therefore, the use of body fluids such as serum, plasma, urine, and salivary secretions can help find cancer biomarkers using technologies related to EXOs.
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spelling pubmed-105662902023-10-12 The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review Jafari, Ali Karimabadi, Keyvan Rahimi, Aso Rostaminasab, Gelavizh Khazaei, Mozafar Rezakhani, Leila Ahmadi jouybari, Touraj Technol Cancer Res Treat Emerging roles of Extracellular Vesicles in cancer research and therapy A significant number of cancer-related deaths are recorded globally each year, despite attempts to cure this illness. Medical science is working to develop new medication therapies as well as to find ways to identify this illness as early as possible, even using noninvasive techniques. Early detection of cancer can greatly aid its treatment. Studies into cancer diagnosis and therapy have recently shifted their focus to exosome (EXO) biomarkers, which comprise numerous RNA and proteins. EXOs are minuscule goblet vesicles that have a width of 30 to 140 nm and are released by a variety of cells, including immune, stem, and tumor cells, as well as bodily fluids. According to a growing body of research, EXOs, and cancer appear to be related. EXOs from tumors play a role in the genetic information transfer between tumor and basal cells, which controls angiogenesis and fosters tumor development and spread. To identify malignant activities early on, microRNAs (miRNAs) from cancers can be extracted from circulatory system EXOs. Specific markers can be used to identify cancer-derived EXOs containing miRNAs, which may be more reliable and precise for early detection. Conventional solid biopsy has become increasingly limited as precision and personalized medicine has advanced, while liquid biopsy offers a viable platform for noninvasive diagnosis and prognosis. Therefore, the use of body fluids such as serum, plasma, urine, and salivary secretions can help find cancer biomarkers using technologies related to EXOs. SAGE Publications 2023-10-11 /pmc/articles/PMC10566290/ /pubmed/37817634 http://dx.doi.org/10.1177/15330338231205999 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Emerging roles of Extracellular Vesicles in cancer research and therapy
Jafari, Ali
Karimabadi, Keyvan
Rahimi, Aso
Rostaminasab, Gelavizh
Khazaei, Mozafar
Rezakhani, Leila
Ahmadi jouybari, Touraj
The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review
title The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review
title_full The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review
title_fullStr The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review
title_full_unstemmed The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review
title_short The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review
title_sort emerging role of exosomal mirnas as biomarkers for early cancer detection: a comprehensive literature review
topic Emerging roles of Extracellular Vesicles in cancer research and therapy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566290/
https://www.ncbi.nlm.nih.gov/pubmed/37817634
http://dx.doi.org/10.1177/15330338231205999
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