Emerging roles of the CIP2A–TopBP1 complex in genome integrity

CIP2A is an inhibitor of the tumour suppressor protein phosphatase 2A. Recently, CIP2A was identified as a synthetic lethal interactor of BRCA1 and BRCA2 and a driver of basal-like breast cancers. In addition, a joint role of TopBP1 (topoisomerase IIβ-binding protein 1) and CIP2A for maintaining gen...

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Autores principales: Ummethum, Henning, Li, Jiayi, Lisby, Michael, Oestergaard, Vibe H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Short Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566317/
https://www.ncbi.nlm.nih.gov/pubmed/37829116
http://dx.doi.org/10.1093/narcan/zcad052
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author Ummethum, Henning
Li, Jiayi
Lisby, Michael
Oestergaard, Vibe H
author_facet Ummethum, Henning
Li, Jiayi
Lisby, Michael
Oestergaard, Vibe H
author_sort Ummethum, Henning
collection PubMed
description CIP2A is an inhibitor of the tumour suppressor protein phosphatase 2A. Recently, CIP2A was identified as a synthetic lethal interactor of BRCA1 and BRCA2 and a driver of basal-like breast cancers. In addition, a joint role of TopBP1 (topoisomerase IIβ-binding protein 1) and CIP2A for maintaining genome integrity during mitosis was discovered. TopBP1 has multiple functions as it is a scaffold for proteins involved in DNA replication, transcriptional regulation, cell cycle regulation and DNA repair. Here, we briefly review details of the CIP2A–TopBP1 interaction, its role in maintaining genome integrity, its involvement in cancer and its potential as a therapeutic target.
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spelling pubmed-105663172023-10-12 Emerging roles of the CIP2A–TopBP1 complex in genome integrity Ummethum, Henning Li, Jiayi Lisby, Michael Oestergaard, Vibe H NAR Cancer Short Review CIP2A is an inhibitor of the tumour suppressor protein phosphatase 2A. Recently, CIP2A was identified as a synthetic lethal interactor of BRCA1 and BRCA2 and a driver of basal-like breast cancers. In addition, a joint role of TopBP1 (topoisomerase IIβ-binding protein 1) and CIP2A for maintaining genome integrity during mitosis was discovered. TopBP1 has multiple functions as it is a scaffold for proteins involved in DNA replication, transcriptional regulation, cell cycle regulation and DNA repair. Here, we briefly review details of the CIP2A–TopBP1 interaction, its role in maintaining genome integrity, its involvement in cancer and its potential as a therapeutic target. Oxford University Press 2023-10-11 /pmc/articles/PMC10566317/ /pubmed/37829116 http://dx.doi.org/10.1093/narcan/zcad052 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of NAR Cancer. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Short Review
Ummethum, Henning
Li, Jiayi
Lisby, Michael
Oestergaard, Vibe H
Emerging roles of the CIP2A–TopBP1 complex in genome integrity
title Emerging roles of the CIP2A–TopBP1 complex in genome integrity
title_full Emerging roles of the CIP2A–TopBP1 complex in genome integrity
title_fullStr Emerging roles of the CIP2A–TopBP1 complex in genome integrity
title_full_unstemmed Emerging roles of the CIP2A–TopBP1 complex in genome integrity
title_short Emerging roles of the CIP2A–TopBP1 complex in genome integrity
title_sort emerging roles of the cip2a–topbp1 complex in genome integrity
topic Short Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566317/
https://www.ncbi.nlm.nih.gov/pubmed/37829116
http://dx.doi.org/10.1093/narcan/zcad052
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