Cargando…
Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine
Antimicrobial resistance recognised as a major global health problem and it poses a significant challenge in conflict zones, such as the Russia-Ukraine war. This case study focuses on a 32-year-old soldier who sustained combat-related injuries, including extensive wound infections caused by multidru...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566362/ https://www.ncbi.nlm.nih.gov/pubmed/37828939 http://dx.doi.org/10.3389/fmed.2023.1264492 |
_version_ | 1785118908364095488 |
---|---|
author | Kryzhevskyi, Vadym Strokous, Viktor Lifshyts, Yurii Rybianets, Yurii Oberniak, Artem Krikunov, Alexey Iungin, Olga Potochilova, Viktoria Rudnieva, Kateryna Petakh, Pavlo Kamyshnyi, Aleksandr Moshynets, Olena |
author_facet | Kryzhevskyi, Vadym Strokous, Viktor Lifshyts, Yurii Rybianets, Yurii Oberniak, Artem Krikunov, Alexey Iungin, Olga Potochilova, Viktoria Rudnieva, Kateryna Petakh, Pavlo Kamyshnyi, Aleksandr Moshynets, Olena |
author_sort | Kryzhevskyi, Vadym |
collection | PubMed |
description | Antimicrobial resistance recognised as a major global health problem and it poses a significant challenge in conflict zones, such as the Russia-Ukraine war. This case study focuses on a 32-year-old soldier who sustained combat-related injuries, including extensive wound infections caused by multidrug-resistant and pan-resistant bacteria and was successfully treated with azithromycin-meropenem combination therapy. The emergence of pan-resistant bacteria, particularly a pandrug-resistant strain of Pseudomonas aeruginosa, highlights the severity of the problem and the limited treatment options available. Additionally, the financial burden posed by reserve antibiotics further complicates the management of these infections. The case study demonstrates the effectiveness of including azithromycin-meropenem combination therapy in the treatment regimen, which resulted in improvements in the patient’s condition and the eradication of the resistant strains. The findings underscore the need for effective antimicrobial stewardship, infection control measures, and alternative treatment strategies to combat antimicrobial resistance in conflict zones. |
format | Online Article Text |
id | pubmed-10566362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105663622023-10-12 Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine Kryzhevskyi, Vadym Strokous, Viktor Lifshyts, Yurii Rybianets, Yurii Oberniak, Artem Krikunov, Alexey Iungin, Olga Potochilova, Viktoria Rudnieva, Kateryna Petakh, Pavlo Kamyshnyi, Aleksandr Moshynets, Olena Front Med (Lausanne) Medicine Antimicrobial resistance recognised as a major global health problem and it poses a significant challenge in conflict zones, such as the Russia-Ukraine war. This case study focuses on a 32-year-old soldier who sustained combat-related injuries, including extensive wound infections caused by multidrug-resistant and pan-resistant bacteria and was successfully treated with azithromycin-meropenem combination therapy. The emergence of pan-resistant bacteria, particularly a pandrug-resistant strain of Pseudomonas aeruginosa, highlights the severity of the problem and the limited treatment options available. Additionally, the financial burden posed by reserve antibiotics further complicates the management of these infections. The case study demonstrates the effectiveness of including azithromycin-meropenem combination therapy in the treatment regimen, which resulted in improvements in the patient’s condition and the eradication of the resistant strains. The findings underscore the need for effective antimicrobial stewardship, infection control measures, and alternative treatment strategies to combat antimicrobial resistance in conflict zones. Frontiers Media S.A. 2023-09-22 /pmc/articles/PMC10566362/ /pubmed/37828939 http://dx.doi.org/10.3389/fmed.2023.1264492 Text en Copyright © 2023 Kryzhevskyi, Strokous, Lifshyts, Rybianets, Oberniak, Krikunov, Iungin, Potochilova, Rudnieva, Petakh, Kamyshnyi and Moshynets. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Kryzhevskyi, Vadym Strokous, Viktor Lifshyts, Yurii Rybianets, Yurii Oberniak, Artem Krikunov, Alexey Iungin, Olga Potochilova, Viktoria Rudnieva, Kateryna Petakh, Pavlo Kamyshnyi, Aleksandr Moshynets, Olena Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine |
title | Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine |
title_full | Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine |
title_fullStr | Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine |
title_full_unstemmed | Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine |
title_short | Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine |
title_sort | case report: azithromycin-meropenem combination therapy as a low-cost approach to combat pdr gram-negative infections of war wounds in ukraine |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566362/ https://www.ncbi.nlm.nih.gov/pubmed/37828939 http://dx.doi.org/10.3389/fmed.2023.1264492 |
work_keys_str_mv | AT kryzhevskyivadym casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT strokousviktor casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT lifshytsyurii casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT rybianetsyurii casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT oberniakartem casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT krikunovalexey casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT iunginolga casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT potochilovaviktoria casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT rudnievakateryna casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT petakhpavlo casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT kamyshnyialeksandr casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine AT moshynetsolena casereportazithromycinmeropenemcombinationtherapyasalowcostapproachtocombatpdrgramnegativeinfectionsofwarwoundsinukraine |