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Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine

Antimicrobial resistance recognised as a major global health problem and it poses a significant challenge in conflict zones, such as the Russia-Ukraine war. This case study focuses on a 32-year-old soldier who sustained combat-related injuries, including extensive wound infections caused by multidru...

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Autores principales: Kryzhevskyi, Vadym, Strokous, Viktor, Lifshyts, Yurii, Rybianets, Yurii, Oberniak, Artem, Krikunov, Alexey, Iungin, Olga, Potochilova, Viktoria, Rudnieva, Kateryna, Petakh, Pavlo, Kamyshnyi, Aleksandr, Moshynets, Olena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566362/
https://www.ncbi.nlm.nih.gov/pubmed/37828939
http://dx.doi.org/10.3389/fmed.2023.1264492
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author Kryzhevskyi, Vadym
Strokous, Viktor
Lifshyts, Yurii
Rybianets, Yurii
Oberniak, Artem
Krikunov, Alexey
Iungin, Olga
Potochilova, Viktoria
Rudnieva, Kateryna
Petakh, Pavlo
Kamyshnyi, Aleksandr
Moshynets, Olena
author_facet Kryzhevskyi, Vadym
Strokous, Viktor
Lifshyts, Yurii
Rybianets, Yurii
Oberniak, Artem
Krikunov, Alexey
Iungin, Olga
Potochilova, Viktoria
Rudnieva, Kateryna
Petakh, Pavlo
Kamyshnyi, Aleksandr
Moshynets, Olena
author_sort Kryzhevskyi, Vadym
collection PubMed
description Antimicrobial resistance recognised as a major global health problem and it poses a significant challenge in conflict zones, such as the Russia-Ukraine war. This case study focuses on a 32-year-old soldier who sustained combat-related injuries, including extensive wound infections caused by multidrug-resistant and pan-resistant bacteria and was successfully treated with azithromycin-meropenem combination therapy. The emergence of pan-resistant bacteria, particularly a pandrug-resistant strain of Pseudomonas aeruginosa, highlights the severity of the problem and the limited treatment options available. Additionally, the financial burden posed by reserve antibiotics further complicates the management of these infections. The case study demonstrates the effectiveness of including azithromycin-meropenem combination therapy in the treatment regimen, which resulted in improvements in the patient’s condition and the eradication of the resistant strains. The findings underscore the need for effective antimicrobial stewardship, infection control measures, and alternative treatment strategies to combat antimicrobial resistance in conflict zones.
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spelling pubmed-105663622023-10-12 Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine Kryzhevskyi, Vadym Strokous, Viktor Lifshyts, Yurii Rybianets, Yurii Oberniak, Artem Krikunov, Alexey Iungin, Olga Potochilova, Viktoria Rudnieva, Kateryna Petakh, Pavlo Kamyshnyi, Aleksandr Moshynets, Olena Front Med (Lausanne) Medicine Antimicrobial resistance recognised as a major global health problem and it poses a significant challenge in conflict zones, such as the Russia-Ukraine war. This case study focuses on a 32-year-old soldier who sustained combat-related injuries, including extensive wound infections caused by multidrug-resistant and pan-resistant bacteria and was successfully treated with azithromycin-meropenem combination therapy. The emergence of pan-resistant bacteria, particularly a pandrug-resistant strain of Pseudomonas aeruginosa, highlights the severity of the problem and the limited treatment options available. Additionally, the financial burden posed by reserve antibiotics further complicates the management of these infections. The case study demonstrates the effectiveness of including azithromycin-meropenem combination therapy in the treatment regimen, which resulted in improvements in the patient’s condition and the eradication of the resistant strains. The findings underscore the need for effective antimicrobial stewardship, infection control measures, and alternative treatment strategies to combat antimicrobial resistance in conflict zones. Frontiers Media S.A. 2023-09-22 /pmc/articles/PMC10566362/ /pubmed/37828939 http://dx.doi.org/10.3389/fmed.2023.1264492 Text en Copyright © 2023 Kryzhevskyi, Strokous, Lifshyts, Rybianets, Oberniak, Krikunov, Iungin, Potochilova, Rudnieva, Petakh, Kamyshnyi and Moshynets. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Kryzhevskyi, Vadym
Strokous, Viktor
Lifshyts, Yurii
Rybianets, Yurii
Oberniak, Artem
Krikunov, Alexey
Iungin, Olga
Potochilova, Viktoria
Rudnieva, Kateryna
Petakh, Pavlo
Kamyshnyi, Aleksandr
Moshynets, Olena
Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine
title Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine
title_full Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine
title_fullStr Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine
title_full_unstemmed Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine
title_short Case report: Azithromycin-meropenem combination therapy as a low-cost approach to combat PDR gram-negative infections of war wounds in Ukraine
title_sort case report: azithromycin-meropenem combination therapy as a low-cost approach to combat pdr gram-negative infections of war wounds in ukraine
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566362/
https://www.ncbi.nlm.nih.gov/pubmed/37828939
http://dx.doi.org/10.3389/fmed.2023.1264492
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