IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway

The aim of this study was to investigate how the concentration of interleukin-13 (IL-13) affects the regulation of endothelial cell migration after injury. The incubation of recombinant human interleukin-13 (rhIL-13) strongly increased the content of reactive oxygen species (ROS) in HUVECs via the J...

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Detalles Bibliográficos
Autores principales: Li, Qi, Li, Yue, Wu, Fengjiao, Li, Jingyu, Li, Zhongsha, Qin, Xiaoling, Wei, Simeng, Chen, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566387/
https://www.ncbi.nlm.nih.gov/pubmed/37814455
http://dx.doi.org/10.1080/19336918.2023.2265158
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author Li, Qi
Li, Yue
Wu, Fengjiao
Li, Jingyu
Li, Zhongsha
Qin, Xiaoling
Wei, Simeng
Chen, Chang
author_facet Li, Qi
Li, Yue
Wu, Fengjiao
Li, Jingyu
Li, Zhongsha
Qin, Xiaoling
Wei, Simeng
Chen, Chang
author_sort Li, Qi
collection PubMed
description The aim of this study was to investigate how the concentration of interleukin-13 (IL-13) affects the regulation of endothelial cell migration after injury. The incubation of recombinant human interleukin-13 (rhIL-13) strongly increased the content of reactive oxygen species (ROS) in HUVECs via the JAK-1/STAT-3/NOX-4 signaling pathway. Antagonizing the high intracellular ROS that was induced by rhIL-13 promoted the migration of HUVECs. Furthermore, IL-13 neutralization not only inhibited intimal hyperplasia, but also promoted the migration of endothelial cells (ECs) after injury. The results suggest that IL-13 inhibition is a potential means of stimulating endothelial cells recovery after injury. Therefore, the attenuation of IL-13 activation may have therapeutic value for vascular disease.
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spelling pubmed-105663872023-10-12 IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway Li, Qi Li, Yue Wu, Fengjiao Li, Jingyu Li, Zhongsha Qin, Xiaoling Wei, Simeng Chen, Chang Cell Adh Migr Research Paper The aim of this study was to investigate how the concentration of interleukin-13 (IL-13) affects the regulation of endothelial cell migration after injury. The incubation of recombinant human interleukin-13 (rhIL-13) strongly increased the content of reactive oxygen species (ROS) in HUVECs via the JAK-1/STAT-3/NOX-4 signaling pathway. Antagonizing the high intracellular ROS that was induced by rhIL-13 promoted the migration of HUVECs. Furthermore, IL-13 neutralization not only inhibited intimal hyperplasia, but also promoted the migration of endothelial cells (ECs) after injury. The results suggest that IL-13 inhibition is a potential means of stimulating endothelial cells recovery after injury. Therefore, the attenuation of IL-13 activation may have therapeutic value for vascular disease. Taylor & Francis 2023-10-09 /pmc/articles/PMC10566387/ /pubmed/37814455 http://dx.doi.org/10.1080/19336918.2023.2265158 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Research Paper
Li, Qi
Li, Yue
Wu, Fengjiao
Li, Jingyu
Li, Zhongsha
Qin, Xiaoling
Wei, Simeng
Chen, Chang
IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway
title IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway
title_full IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway
title_fullStr IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway
title_full_unstemmed IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway
title_short IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway
title_sort il-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the jak-1/stat-3 signaling pathway
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566387/
https://www.ncbi.nlm.nih.gov/pubmed/37814455
http://dx.doi.org/10.1080/19336918.2023.2265158
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