Indoleamine 2,3-Dioxygenase Deletion to Modulate Kynurenine Pathway and to Prevent Brain Injury after Cardiac Arrest in Mice

BACKGROUND: The catabolism of the essential amino acid tryptophan to kynurenine is emerging as a potential key pathway involved in post–cardiac arrest brain injury. The aim of this study was to evaluate the effects of the modulation of kynurenine pathway on cardiac arrest outcome through genetic del...

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Detalles Bibliográficos
Autores principales: Magliocca, Aurora, Perego, Carlo, Motta, Francesca, Merigo, Giulia, Micotti, Edoardo, Olivari, Davide, Fumagalli, Francesca, Lucchetti, Jacopo, Gobbi, Marco, Mandelli, Alessandra, Furlan, Roberto, Skrifvars, Markus B., Latini, Roberto, Bellani, Giacomo, Ichinose, Fumito, Ristagno, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Critical Care Medicine: Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566599/
https://www.ncbi.nlm.nih.gov/pubmed/37487175
http://dx.doi.org/10.1097/ALN.0000000000004713

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