Safety of Xiaflex® (Collagenase Clostridium histolyticum) Treatment for Adult Anterior Urethral Stricture Disease

Male urethral stricture disease is highly prevalent and difficult to treat due to potential complications. Minimally invasive treatments tend to have high recurrence rates, keeping urethroplasty as the gold standard. Collagenase Clostridium histolyticum (CCH) has been used in humans to treat fibrosi...

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Detalles Bibliográficos
Autores principales: Wiegand, Lucas R, Tran, Thanh Q, Heinsimer, Kevin, Shah, Bhavik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Urology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566641/
https://www.ncbi.nlm.nih.gov/pubmed/37829978
http://dx.doi.org/10.7759/cureus.45051
Descripción
Sumario:Male urethral stricture disease is highly prevalent and difficult to treat due to potential complications. Minimally invasive treatments tend to have high recurrence rates, keeping urethroplasty as the gold standard. Collagenase Clostridium histolyticum (CCH) has been used in humans to treat fibrosis in a minimally invasive manner. Herein, we present the preliminary results from treatments of three males with urethral stricture as a feasibility and safety evaluation of the first-in-human CCH treatment for male urethral stricture disease.

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