Safety of Xiaflex® (Collagenase Clostridium histolyticum) Treatment for Adult Anterior Urethral Stricture Disease

Male urethral stricture disease is highly prevalent and difficult to treat due to potential complications. Minimally invasive treatments tend to have high recurrence rates, keeping urethroplasty as the gold standard. Collagenase Clostridium histolyticum (CCH) has been used in humans to treat fibrosi...

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Detalles Bibliográficos
Autores principales: Wiegand, Lucas R, Tran, Thanh Q, Heinsimer, Kevin, Shah, Bhavik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Urology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566641/
https://www.ncbi.nlm.nih.gov/pubmed/37829978
http://dx.doi.org/10.7759/cureus.45051
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author Wiegand, Lucas R
Tran, Thanh Q
Heinsimer, Kevin
Shah, Bhavik
author_facet Wiegand, Lucas R
Tran, Thanh Q
Heinsimer, Kevin
Shah, Bhavik
author_sort Wiegand, Lucas R
collection PubMed
description Male urethral stricture disease is highly prevalent and difficult to treat due to potential complications. Minimally invasive treatments tend to have high recurrence rates, keeping urethroplasty as the gold standard. Collagenase Clostridium histolyticum (CCH) has been used in humans to treat fibrosis in a minimally invasive manner. Herein, we present the preliminary results from treatments of three males with urethral stricture as a feasibility and safety evaluation of the first-in-human CCH treatment for male urethral stricture disease.
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spelling pubmed-105666412023-10-12 Safety of Xiaflex® (Collagenase Clostridium histolyticum) Treatment for Adult Anterior Urethral Stricture Disease Wiegand, Lucas R Tran, Thanh Q Heinsimer, Kevin Shah, Bhavik Cureus Urology Male urethral stricture disease is highly prevalent and difficult to treat due to potential complications. Minimally invasive treatments tend to have high recurrence rates, keeping urethroplasty as the gold standard. Collagenase Clostridium histolyticum (CCH) has been used in humans to treat fibrosis in a minimally invasive manner. Herein, we present the preliminary results from treatments of three males with urethral stricture as a feasibility and safety evaluation of the first-in-human CCH treatment for male urethral stricture disease. Cureus 2023-09-11 /pmc/articles/PMC10566641/ /pubmed/37829978 http://dx.doi.org/10.7759/cureus.45051 Text en Copyright © 2023, Wiegand et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Urology
Wiegand, Lucas R
Tran, Thanh Q
Heinsimer, Kevin
Shah, Bhavik
Safety of Xiaflex® (Collagenase Clostridium histolyticum) Treatment for Adult Anterior Urethral Stricture Disease
title Safety of Xiaflex® (Collagenase Clostridium histolyticum) Treatment for Adult Anterior Urethral Stricture Disease
title_full Safety of Xiaflex® (Collagenase Clostridium histolyticum) Treatment for Adult Anterior Urethral Stricture Disease
title_fullStr Safety of Xiaflex® (Collagenase Clostridium histolyticum) Treatment for Adult Anterior Urethral Stricture Disease
title_full_unstemmed Safety of Xiaflex® (Collagenase Clostridium histolyticum) Treatment for Adult Anterior Urethral Stricture Disease
title_short Safety of Xiaflex® (Collagenase Clostridium histolyticum) Treatment for Adult Anterior Urethral Stricture Disease
title_sort safety of xiaflex® (collagenase clostridium histolyticum) treatment for adult anterior urethral stricture disease
topic Urology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566641/
https://www.ncbi.nlm.nih.gov/pubmed/37829978
http://dx.doi.org/10.7759/cureus.45051
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