Cargando…

Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study

INTRODUCTION: The burden of cardiovascular disease (CVD) is huge due to its associated morbidity, mortality and adverse socio-economic impact. Environmental pollution as a risk factor contributes significantly to the burden of CVD, especially in the low and middle income countries. One of the effect...

Descripción completa

Detalles Bibliográficos
Autores principales: Adejumo, Oluseyi Ademola, Enikuomehin, Adenike Christianah, Ogunleye, Adeyemi, Osungbemiro, Walter Bamikole, Adelosoye, Alex Adedotun, Akinbodewa, Ayodeji Akinwumi, Lawal, Olutoyin Morenike, Ngoka, Stanley Chidozie, Junaid, Oladimeji Adedeji, Okonkwo, Kenechukwu, Alli, Emmanuel Oladimeji, Oloyede, Rasheed Olanshile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566715/
https://www.ncbi.nlm.nih.gov/pubmed/37819988
http://dx.doi.org/10.1371/journal.pone.0292364
_version_ 1785118970763804672
author Adejumo, Oluseyi Ademola
Enikuomehin, Adenike Christianah
Ogunleye, Adeyemi
Osungbemiro, Walter Bamikole
Adelosoye, Alex Adedotun
Akinbodewa, Ayodeji Akinwumi
Lawal, Olutoyin Morenike
Ngoka, Stanley Chidozie
Junaid, Oladimeji Adedeji
Okonkwo, Kenechukwu
Alli, Emmanuel Oladimeji
Oloyede, Rasheed Olanshile
author_facet Adejumo, Oluseyi Ademola
Enikuomehin, Adenike Christianah
Ogunleye, Adeyemi
Osungbemiro, Walter Bamikole
Adelosoye, Alex Adedotun
Akinbodewa, Ayodeji Akinwumi
Lawal, Olutoyin Morenike
Ngoka, Stanley Chidozie
Junaid, Oladimeji Adedeji
Okonkwo, Kenechukwu
Alli, Emmanuel Oladimeji
Oloyede, Rasheed Olanshile
author_sort Adejumo, Oluseyi Ademola
collection PubMed
description INTRODUCTION: The burden of cardiovascular disease (CVD) is huge due to its associated morbidity, mortality and adverse socio-economic impact. Environmental pollution as a risk factor contributes significantly to the burden of CVD, especially in the low and middle income countries. One of the effective strategies to reduce CVD burden is to prevent or detect cardiovascular risk factors early in at-risk population. This study determined some cardiovascular risk factors, kidney function, and their association with heavy metals among automobile mechanics. METHOD: This was a cross-sectional study involving 162 automobile mechanics and 81 age and sex matched controls. Serum levels of lead, cadmium and some cardiovascular risks were assessed and compared in the two groups. Associations between serum lead, cadmium and some cardiovascular risks were determined using correlation analysis. P value of <0.05 was taken as significant. RESULTS: The mean ages of the automobile mechanics and controls were 47.27±9.99 years and 48.94±10.34 years, respectively. The prevalence of elevated serum cadmium was significantly higher in the automobile mechanics (25.9% vs 7.9%; p = <0.001). The significant cardiovascular risk factors in the automobile mechanics vs controls were elevated total cholesterol (32.1% vs 18.5%; p = 0.017), hyperuricemia (20.4% vs 1.2%; p = <0.001), elevated blood glucose (16.0% vs 4.9% p = 0.013); and alcohol use (55.1% vs 30.0%; p = 0.001). Among the automobile mechanics, there were significant positive correlations between serum cadmium, atherogenic index of plasma (AIP) (p = 0.024; r = 0.382) and triglyceride (p = 0.020; r = 0.391). Significant positive correlation was found between serum lead and neutrophil gelatinase associated lipocalin (NGAL) (p = <0.001; r = 0.329). There were significant positive correlation between serum cadmium level, AIP (p = 0.016; r = 0.373) and TG (p = 0.004; r = 0.439); between serum lead and NGAL in all the study participants (p = 0.005; r = 0.206). CONCLUSION: Automobile mechanics have notable exposure to heavy metals and a higher prevalence of some cardiovascular risk factors. Health education and sensitisation as well as policies that would regulate exposure of persons to heavy metals should be implemented in Nigeria.
format Online
Article
Text
id pubmed-10566715
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-105667152023-10-12 Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study Adejumo, Oluseyi Ademola Enikuomehin, Adenike Christianah Ogunleye, Adeyemi Osungbemiro, Walter Bamikole Adelosoye, Alex Adedotun Akinbodewa, Ayodeji Akinwumi Lawal, Olutoyin Morenike Ngoka, Stanley Chidozie Junaid, Oladimeji Adedeji Okonkwo, Kenechukwu Alli, Emmanuel Oladimeji Oloyede, Rasheed Olanshile PLoS One Research Article INTRODUCTION: The burden of cardiovascular disease (CVD) is huge due to its associated morbidity, mortality and adverse socio-economic impact. Environmental pollution as a risk factor contributes significantly to the burden of CVD, especially in the low and middle income countries. One of the effective strategies to reduce CVD burden is to prevent or detect cardiovascular risk factors early in at-risk population. This study determined some cardiovascular risk factors, kidney function, and their association with heavy metals among automobile mechanics. METHOD: This was a cross-sectional study involving 162 automobile mechanics and 81 age and sex matched controls. Serum levels of lead, cadmium and some cardiovascular risks were assessed and compared in the two groups. Associations between serum lead, cadmium and some cardiovascular risks were determined using correlation analysis. P value of <0.05 was taken as significant. RESULTS: The mean ages of the automobile mechanics and controls were 47.27±9.99 years and 48.94±10.34 years, respectively. The prevalence of elevated serum cadmium was significantly higher in the automobile mechanics (25.9% vs 7.9%; p = <0.001). The significant cardiovascular risk factors in the automobile mechanics vs controls were elevated total cholesterol (32.1% vs 18.5%; p = 0.017), hyperuricemia (20.4% vs 1.2%; p = <0.001), elevated blood glucose (16.0% vs 4.9% p = 0.013); and alcohol use (55.1% vs 30.0%; p = 0.001). Among the automobile mechanics, there were significant positive correlations between serum cadmium, atherogenic index of plasma (AIP) (p = 0.024; r = 0.382) and triglyceride (p = 0.020; r = 0.391). Significant positive correlation was found between serum lead and neutrophil gelatinase associated lipocalin (NGAL) (p = <0.001; r = 0.329). There were significant positive correlation between serum cadmium level, AIP (p = 0.016; r = 0.373) and TG (p = 0.004; r = 0.439); between serum lead and NGAL in all the study participants (p = 0.005; r = 0.206). CONCLUSION: Automobile mechanics have notable exposure to heavy metals and a higher prevalence of some cardiovascular risk factors. Health education and sensitisation as well as policies that would regulate exposure of persons to heavy metals should be implemented in Nigeria. Public Library of Science 2023-10-11 /pmc/articles/PMC10566715/ /pubmed/37819988 http://dx.doi.org/10.1371/journal.pone.0292364 Text en © 2023 Adejumo et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Adejumo, Oluseyi Ademola
Enikuomehin, Adenike Christianah
Ogunleye, Adeyemi
Osungbemiro, Walter Bamikole
Adelosoye, Alex Adedotun
Akinbodewa, Ayodeji Akinwumi
Lawal, Olutoyin Morenike
Ngoka, Stanley Chidozie
Junaid, Oladimeji Adedeji
Okonkwo, Kenechukwu
Alli, Emmanuel Oladimeji
Oloyede, Rasheed Olanshile
Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study
title Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study
title_full Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study
title_fullStr Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study
title_full_unstemmed Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study
title_short Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study
title_sort cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in southwest nigeria: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566715/
https://www.ncbi.nlm.nih.gov/pubmed/37819988
http://dx.doi.org/10.1371/journal.pone.0292364
work_keys_str_mv AT adejumooluseyiademola cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT enikuomehinadenikechristianah cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT ogunleyeadeyemi cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT osungbemirowalterbamikole cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT adelosoyealexadedotun cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT akinbodewaayodejiakinwumi cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT lawalolutoyinmorenike cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT ngokastanleychidozie cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT junaidoladimejiadedeji cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT okonkwokenechukwu cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT alliemmanueloladimeji cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy
AT oloyederasheedolanshile cardiovascularriskfactorsandkidneyfunctionamongautomobilemechanicandtheirassociationwithserumheavymetalsinsouthwestnigeriaacrosssectionalstudy