TAT peptide at treatment-level concentrations crossed brain endothelial cell monolayer independent of receptor-mediated endocytosis or peptide-inflicted barrier disruption

The peptide domain extending from residues 49 to 57 of the HIV-1 Tat protein (TAT) has been widely shown to facilitate cell entry of and blood-brain barrier (BBB) permeability to covalently bound macromolecules; therefore, TAT-linked therapeutic peptides trafficked through peripheral routes have bee...

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Detalles Bibliográficos
Autores principales: Wu, Meng-Chih, Wang, Eric Yuhsiang, Lai, Ted Weita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566733/
https://www.ncbi.nlm.nih.gov/pubmed/37819924
http://dx.doi.org/10.1371/journal.pone.0292681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566733/
https://www.ncbi.nlm.nih.gov/pubmed/37819924
http://dx.doi.org/10.1371/journal.pone.0292681

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