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Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings
OBJECTIVE: To evaluate the accuracy of preoperative positron emission tomography/computed tomography with (68)Ga-labeled prostate-specific membrane antigen ((68)Ga-PSMA PET/CT) for staging prostate cancer and compare it with magnetic resonance imaging (MRI) using histopathology of surgical specimens...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567085/ https://www.ncbi.nlm.nih.gov/pubmed/37829589 http://dx.doi.org/10.1590/0100-3984.2022.0122-en |
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author | Stasiak, Camila Edith Stachera Cardillo, Athos de Almeida, Sergio Altino Rodrigues, Rosana Souza de Castro, Paulo Henrique Rosado Parente, Daniella Braz |
author_facet | Stasiak, Camila Edith Stachera Cardillo, Athos de Almeida, Sergio Altino Rodrigues, Rosana Souza de Castro, Paulo Henrique Rosado Parente, Daniella Braz |
author_sort | Stasiak, Camila Edith Stachera |
collection | PubMed |
description | OBJECTIVE: To evaluate the accuracy of preoperative positron emission tomography/computed tomography with (68)Ga-labeled prostate-specific membrane antigen ((68)Ga-PSMA PET/CT) for staging prostate cancer and compare it with magnetic resonance imaging (MRI) using histopathology of surgical specimens as the gold standard. MATERIALS AND METHODS: In this retrospective study, 65 patients with prostate cancer were analyzed. RESULTS: The accuracy of (68)Ga-PSMA PET/CT for tumor detection was 95%, and that of MRI was 91%. There was no difference between (68)Ga-PSMA PET/CT and MRI regarding localization of the lesion. The sensitivity of (68)Ga-PSMA PET/CT for detecting extraprostatic extension was quite low (14%). For detection of seminal vesicle invasion, (68)Ga-PSMA PET/CT showed a sensitivity of 57% and accuracy of 91%. There was a moderate correlation between the maximum standardized uptake value (SUVmax) and the serum level of prostate-specific antigen (p < 0.01; ρ = 0.368) and between the SUVmax and the International Society of Urological Pathology (ISUP) grade (p < 0.01; ρ = 0.513). CONCLUSION: (68)Ga-PSMA PET/CT is a promising tool for detecting and evaluating the primary tumor, which can alter the staging and management of the disease. |
format | Online Article Text |
id | pubmed-10567085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
record_format | MEDLINE/PubMed |
spelling | pubmed-105670852023-10-12 Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings Stasiak, Camila Edith Stachera Cardillo, Athos de Almeida, Sergio Altino Rodrigues, Rosana Souza de Castro, Paulo Henrique Rosado Parente, Daniella Braz Radiol Bras Original Article OBJECTIVE: To evaluate the accuracy of preoperative positron emission tomography/computed tomography with (68)Ga-labeled prostate-specific membrane antigen ((68)Ga-PSMA PET/CT) for staging prostate cancer and compare it with magnetic resonance imaging (MRI) using histopathology of surgical specimens as the gold standard. MATERIALS AND METHODS: In this retrospective study, 65 patients with prostate cancer were analyzed. RESULTS: The accuracy of (68)Ga-PSMA PET/CT for tumor detection was 95%, and that of MRI was 91%. There was no difference between (68)Ga-PSMA PET/CT and MRI regarding localization of the lesion. The sensitivity of (68)Ga-PSMA PET/CT for detecting extraprostatic extension was quite low (14%). For detection of seminal vesicle invasion, (68)Ga-PSMA PET/CT showed a sensitivity of 57% and accuracy of 91%. There was a moderate correlation between the maximum standardized uptake value (SUVmax) and the serum level of prostate-specific antigen (p < 0.01; ρ = 0.368) and between the SUVmax and the International Society of Urological Pathology (ISUP) grade (p < 0.01; ρ = 0.513). CONCLUSION: (68)Ga-PSMA PET/CT is a promising tool for detecting and evaluating the primary tumor, which can alter the staging and management of the disease. Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2023 /pmc/articles/PMC10567085/ /pubmed/37829589 http://dx.doi.org/10.1590/0100-3984.2022.0122-en Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Stasiak, Camila Edith Stachera Cardillo, Athos de Almeida, Sergio Altino Rodrigues, Rosana Souza de Castro, Paulo Henrique Rosado Parente, Daniella Braz Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings |
title | Preoperative evaluation of prostate cancer by (68)Ga-PMSA
positron emission tomography/computed tomography: comparison with magnetic
resonance imaging and with histopathological findings |
title_full | Preoperative evaluation of prostate cancer by (68)Ga-PMSA
positron emission tomography/computed tomography: comparison with magnetic
resonance imaging and with histopathological findings |
title_fullStr | Preoperative evaluation of prostate cancer by (68)Ga-PMSA
positron emission tomography/computed tomography: comparison with magnetic
resonance imaging and with histopathological findings |
title_full_unstemmed | Preoperative evaluation of prostate cancer by (68)Ga-PMSA
positron emission tomography/computed tomography: comparison with magnetic
resonance imaging and with histopathological findings |
title_short | Preoperative evaluation of prostate cancer by (68)Ga-PMSA
positron emission tomography/computed tomography: comparison with magnetic
resonance imaging and with histopathological findings |
title_sort | preoperative evaluation of prostate cancer by (68)ga-pmsa
positron emission tomography/computed tomography: comparison with magnetic
resonance imaging and with histopathological findings |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567085/ https://www.ncbi.nlm.nih.gov/pubmed/37829589 http://dx.doi.org/10.1590/0100-3984.2022.0122-en |
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