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Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings

OBJECTIVE: To evaluate the accuracy of preoperative positron emission tomography/computed tomography with (68)Ga-labeled prostate-specific membrane antigen ((68)Ga-PSMA PET/CT) for staging prostate cancer and compare it with magnetic resonance imaging (MRI) using histopathology of surgical specimens...

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Autores principales: Stasiak, Camila Edith Stachera, Cardillo, Athos, de Almeida, Sergio Altino, Rodrigues, Rosana Souza, de Castro, Paulo Henrique Rosado, Parente, Daniella Braz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567085/
https://www.ncbi.nlm.nih.gov/pubmed/37829589
http://dx.doi.org/10.1590/0100-3984.2022.0122-en
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author Stasiak, Camila Edith Stachera
Cardillo, Athos
de Almeida, Sergio Altino
Rodrigues, Rosana Souza
de Castro, Paulo Henrique Rosado
Parente, Daniella Braz
author_facet Stasiak, Camila Edith Stachera
Cardillo, Athos
de Almeida, Sergio Altino
Rodrigues, Rosana Souza
de Castro, Paulo Henrique Rosado
Parente, Daniella Braz
author_sort Stasiak, Camila Edith Stachera
collection PubMed
description OBJECTIVE: To evaluate the accuracy of preoperative positron emission tomography/computed tomography with (68)Ga-labeled prostate-specific membrane antigen ((68)Ga-PSMA PET/CT) for staging prostate cancer and compare it with magnetic resonance imaging (MRI) using histopathology of surgical specimens as the gold standard. MATERIALS AND METHODS: In this retrospective study, 65 patients with prostate cancer were analyzed. RESULTS: The accuracy of (68)Ga-PSMA PET/CT for tumor detection was 95%, and that of MRI was 91%. There was no difference between (68)Ga-PSMA PET/CT and MRI regarding localization of the lesion. The sensitivity of (68)Ga-PSMA PET/CT for detecting extraprostatic extension was quite low (14%). For detection of seminal vesicle invasion, (68)Ga-PSMA PET/CT showed a sensitivity of 57% and accuracy of 91%. There was a moderate correlation between the maximum standardized uptake value (SUVmax) and the serum level of prostate-specific antigen (p < 0.01; ρ = 0.368) and between the SUVmax and the International Society of Urological Pathology (ISUP) grade (p < 0.01; ρ = 0.513). CONCLUSION: (68)Ga-PSMA PET/CT is a promising tool for detecting and evaluating the primary tumor, which can alter the staging and management of the disease.
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spelling pubmed-105670852023-10-12 Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings Stasiak, Camila Edith Stachera Cardillo, Athos de Almeida, Sergio Altino Rodrigues, Rosana Souza de Castro, Paulo Henrique Rosado Parente, Daniella Braz Radiol Bras Original Article OBJECTIVE: To evaluate the accuracy of preoperative positron emission tomography/computed tomography with (68)Ga-labeled prostate-specific membrane antigen ((68)Ga-PSMA PET/CT) for staging prostate cancer and compare it with magnetic resonance imaging (MRI) using histopathology of surgical specimens as the gold standard. MATERIALS AND METHODS: In this retrospective study, 65 patients with prostate cancer were analyzed. RESULTS: The accuracy of (68)Ga-PSMA PET/CT for tumor detection was 95%, and that of MRI was 91%. There was no difference between (68)Ga-PSMA PET/CT and MRI regarding localization of the lesion. The sensitivity of (68)Ga-PSMA PET/CT for detecting extraprostatic extension was quite low (14%). For detection of seminal vesicle invasion, (68)Ga-PSMA PET/CT showed a sensitivity of 57% and accuracy of 91%. There was a moderate correlation between the maximum standardized uptake value (SUVmax) and the serum level of prostate-specific antigen (p < 0.01; ρ = 0.368) and between the SUVmax and the International Society of Urological Pathology (ISUP) grade (p < 0.01; ρ = 0.513). CONCLUSION: (68)Ga-PSMA PET/CT is a promising tool for detecting and evaluating the primary tumor, which can alter the staging and management of the disease. Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2023 /pmc/articles/PMC10567085/ /pubmed/37829589 http://dx.doi.org/10.1590/0100-3984.2022.0122-en Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Stasiak, Camila Edith Stachera
Cardillo, Athos
de Almeida, Sergio Altino
Rodrigues, Rosana Souza
de Castro, Paulo Henrique Rosado
Parente, Daniella Braz
Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings
title Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings
title_full Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings
title_fullStr Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings
title_full_unstemmed Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings
title_short Preoperative evaluation of prostate cancer by (68)Ga-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings
title_sort preoperative evaluation of prostate cancer by (68)ga-pmsa positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567085/
https://www.ncbi.nlm.nih.gov/pubmed/37829589
http://dx.doi.org/10.1590/0100-3984.2022.0122-en
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