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High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators

Two-dimensional (2D) Talbot array illuminators (TAIs) were designed, fabricated, and evaluated for high-resolution high-contrast x-ray phase imaging of soft tissue at 10–20 keV. The TAIs create intensity modulations with a high compression ratio on the micrometer scale at short propagation distances...

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Detalles Bibliográficos
Autores principales: Gustschin, Alex, Riedel, Mirko, Taphorn, Kirsten, Petrich, Christian, Gottwald, Wolfgang, Noichl, Wolfgang, Busse, Madleen, Francis, Sheila E., Beckmann, Felix, Hammel, Jörg U., Moosmann, Julian, Thibault, Pierre, Herzen, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567101/
https://www.ncbi.nlm.nih.gov/pubmed/37829605
http://dx.doi.org/10.1364/OPTICA.441004
Descripción
Sumario:Two-dimensional (2D) Talbot array illuminators (TAIs) were designed, fabricated, and evaluated for high-resolution high-contrast x-ray phase imaging of soft tissue at 10–20 keV. The TAIs create intensity modulations with a high compression ratio on the micrometer scale at short propagation distances. Their performance was compared with various other wavefront markers in terms of period, visibility, flux efficiency, and flexibility to be adapted for limited beam coherence and detector resolution. Differential x-ray phase contrast and dark-field imaging were demonstrated with a one-dimensional, linear phase stepping approach yielding 2D phase sensitivity using unified modulated pattern analysis (UMPA) for phase retrieval. The method was employed for x-ray phase computed tomography reaching a resolution of 3 µm on an unstained murine artery. It opens new possibilities for three-dimensional, non-destructive, and quantitative imaging of soft matter such as virtual histology. The phase modulators can also be used for various other x-ray applications such as dynamic phase imaging, super-resolution structured illumination microscopy, or wavefront sensing.