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High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators
Two-dimensional (2D) Talbot array illuminators (TAIs) were designed, fabricated, and evaluated for high-resolution high-contrast x-ray phase imaging of soft tissue at 10–20 keV. The TAIs create intensity modulations with a high compression ratio on the micrometer scale at short propagation distances...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567101/ https://www.ncbi.nlm.nih.gov/pubmed/37829605 http://dx.doi.org/10.1364/OPTICA.441004 |
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author | Gustschin, Alex Riedel, Mirko Taphorn, Kirsten Petrich, Christian Gottwald, Wolfgang Noichl, Wolfgang Busse, Madleen Francis, Sheila E. Beckmann, Felix Hammel, Jörg U. Moosmann, Julian Thibault, Pierre Herzen, Julia |
author_facet | Gustschin, Alex Riedel, Mirko Taphorn, Kirsten Petrich, Christian Gottwald, Wolfgang Noichl, Wolfgang Busse, Madleen Francis, Sheila E. Beckmann, Felix Hammel, Jörg U. Moosmann, Julian Thibault, Pierre Herzen, Julia |
author_sort | Gustschin, Alex |
collection | PubMed |
description | Two-dimensional (2D) Talbot array illuminators (TAIs) were designed, fabricated, and evaluated for high-resolution high-contrast x-ray phase imaging of soft tissue at 10–20 keV. The TAIs create intensity modulations with a high compression ratio on the micrometer scale at short propagation distances. Their performance was compared with various other wavefront markers in terms of period, visibility, flux efficiency, and flexibility to be adapted for limited beam coherence and detector resolution. Differential x-ray phase contrast and dark-field imaging were demonstrated with a one-dimensional, linear phase stepping approach yielding 2D phase sensitivity using unified modulated pattern analysis (UMPA) for phase retrieval. The method was employed for x-ray phase computed tomography reaching a resolution of 3 µm on an unstained murine artery. It opens new possibilities for three-dimensional, non-destructive, and quantitative imaging of soft matter such as virtual histology. The phase modulators can also be used for various other x-ray applications such as dynamic phase imaging, super-resolution structured illumination microscopy, or wavefront sensing. |
format | Online Article Text |
id | pubmed-10567101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-105671012023-10-12 High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators Gustschin, Alex Riedel, Mirko Taphorn, Kirsten Petrich, Christian Gottwald, Wolfgang Noichl, Wolfgang Busse, Madleen Francis, Sheila E. Beckmann, Felix Hammel, Jörg U. Moosmann, Julian Thibault, Pierre Herzen, Julia Optica Article Two-dimensional (2D) Talbot array illuminators (TAIs) were designed, fabricated, and evaluated for high-resolution high-contrast x-ray phase imaging of soft tissue at 10–20 keV. The TAIs create intensity modulations with a high compression ratio on the micrometer scale at short propagation distances. Their performance was compared with various other wavefront markers in terms of period, visibility, flux efficiency, and flexibility to be adapted for limited beam coherence and detector resolution. Differential x-ray phase contrast and dark-field imaging were demonstrated with a one-dimensional, linear phase stepping approach yielding 2D phase sensitivity using unified modulated pattern analysis (UMPA) for phase retrieval. The method was employed for x-ray phase computed tomography reaching a resolution of 3 µm on an unstained murine artery. It opens new possibilities for three-dimensional, non-destructive, and quantitative imaging of soft matter such as virtual histology. The phase modulators can also be used for various other x-ray applications such as dynamic phase imaging, super-resolution structured illumination microscopy, or wavefront sensing. Optical Society of America 2021-12-10 /pmc/articles/PMC10567101/ /pubmed/37829605 http://dx.doi.org/10.1364/OPTICA.441004 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ 2334-2536/21/121588-08 |
spellingShingle | Article Gustschin, Alex Riedel, Mirko Taphorn, Kirsten Petrich, Christian Gottwald, Wolfgang Noichl, Wolfgang Busse, Madleen Francis, Sheila E. Beckmann, Felix Hammel, Jörg U. Moosmann, Julian Thibault, Pierre Herzen, Julia High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators |
title | High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators |
title_full | High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators |
title_fullStr | High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators |
title_full_unstemmed | High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators |
title_short | High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators |
title_sort | high-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2d talbot array illuminators |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567101/ https://www.ncbi.nlm.nih.gov/pubmed/37829605 http://dx.doi.org/10.1364/OPTICA.441004 |
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