Design and testing of a humanized porcine donor for xenotransplantation

Recent human decedent model studies(1,2) and compassionate xenograft use(3) have explored the promise of porcine organs for human transplantation. To proceed to human studies, a clinically ready porcine donor must be engineered and its xenograft successfully tested in nonhuman primates. Here we desc...

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Detalles Bibliográficos
Autores principales: Anand, Ranjith P., Layer, Jacob V., Heja, David, Hirose, Takayuki, Lassiter, Grace, Firl, Daniel J., Paragas, Violette B., Akkad, Adam, Chhangawala, Sagar, Colvin, Robert B., Ernst, Russell J., Esch, Nicholas, Getchell, Kristen, Griffin, Alexandra K., Guo, Xiaoyun, Hall, Katherine C., Hamilton, Paula, Kalekar, Lokesh A., Kan, Yinan, Karadagi, Ahmad, Li, Feng, Low, Susan C., Matheson, Rudy, Nehring, Claudia, Otsuka, Ryo, Pandelakis, Matthew, Policastro, Robert A., Pols, Rebecca, Queiroz, Luis, Rosales, Ivy A., Serkin, William T., Stiede, Kathryn, Tomosugi, Toshihide, Xue, Yongqiang, Zentner, Gabriel E., Angeles-Albores, David, Chris Chao, J., Crabtree, Juliet N., Harken, Sierra, Hinkle, Nicole, Lemos, Tania, Li, Mailin, Pantano, Lorena, Stevens, Denise, Subedar, Omar D., Tan, Xiaoqing, Yin, Shiyi, Anwar, Imran J., Aufhauser, David, Capuano, Saverio, Kaufman, Dixon B., Knechtle, Stuart J., Kwun, Jean, Shanmuganayagam, Dhanansayan, Markmann, James F., Church, George M., Curtis, Mike, Kawai, Tatsuo, Youd, Michele E., Qin, Wenning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567564/
https://www.ncbi.nlm.nih.gov/pubmed/37821590
http://dx.doi.org/10.1038/s41586-023-06594-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567564/
https://www.ncbi.nlm.nih.gov/pubmed/37821590
http://dx.doi.org/10.1038/s41586-023-06594-4

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