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Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism

In this study, immature persimmon (Diospyros kaki Thunb.) ethanol extract was administered to an obese animal model fed a high-fat diet to measure weight change, adipose tissue weight, serum lipid level, and expression level of adipose-related genes to evaluate its efficacy. Administration of D. kak...

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Autores principales: Yoon, Seon-A, Ham, Young-Min, Han, Sang-Chul, Hyun, Ho Bong, Go, Boram, Jung, Yong-Hwan, Yoo, Eun-Sook, Yoon, Weon-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Food Science and Nutrition 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567593/
https://www.ncbi.nlm.nih.gov/pubmed/37842245
http://dx.doi.org/10.3746/pnf.2023.28.3.263
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author Yoon, Seon-A
Ham, Young-Min
Han, Sang-Chul
Hyun, Ho Bong
Go, Boram
Jung, Yong-Hwan
Yoo, Eun-Sook
Yoon, Weon-Jong
author_facet Yoon, Seon-A
Ham, Young-Min
Han, Sang-Chul
Hyun, Ho Bong
Go, Boram
Jung, Yong-Hwan
Yoo, Eun-Sook
Yoon, Weon-Jong
author_sort Yoon, Seon-A
collection PubMed
description In this study, immature persimmon (Diospyros kaki Thunb.) ethanol extract was administered to an obese animal model fed a high-fat diet to measure weight change, adipose tissue weight, serum lipid level, and expression level of adipose-related genes to evaluate its efficacy. Administration of D. kaki ethanol extract (DKE) (100 and 500 mg/kg/d) decreased the body weight gain, adipose tissue weight, and serum triglyceride levels in mice fed a high-fat diet. Furthermore, it improved the leptin and adiponectin levels in the blood as well as gene expression in the liver. It also inhibited the expression of sterol regulatory element-binding protein-1c, inhibiting the production of triglyceride biosynthetic enzyme fatty acid synthesis and acetyl-CoA carboxylase, and decreased the expressions of peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding proteins that induce adipocyte differentiation. Therefore, these data suggest that DKE exerts beneficial effects on high-fat diet-induced obesity by modulating lipid metabolism in mice fed a high-fat diet.
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spelling pubmed-105675932023-10-13 Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism Yoon, Seon-A Ham, Young-Min Han, Sang-Chul Hyun, Ho Bong Go, Boram Jung, Yong-Hwan Yoo, Eun-Sook Yoon, Weon-Jong Prev Nutr Food Sci Original In this study, immature persimmon (Diospyros kaki Thunb.) ethanol extract was administered to an obese animal model fed a high-fat diet to measure weight change, adipose tissue weight, serum lipid level, and expression level of adipose-related genes to evaluate its efficacy. Administration of D. kaki ethanol extract (DKE) (100 and 500 mg/kg/d) decreased the body weight gain, adipose tissue weight, and serum triglyceride levels in mice fed a high-fat diet. Furthermore, it improved the leptin and adiponectin levels in the blood as well as gene expression in the liver. It also inhibited the expression of sterol regulatory element-binding protein-1c, inhibiting the production of triglyceride biosynthetic enzyme fatty acid synthesis and acetyl-CoA carboxylase, and decreased the expressions of peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding proteins that induce adipocyte differentiation. Therefore, these data suggest that DKE exerts beneficial effects on high-fat diet-induced obesity by modulating lipid metabolism in mice fed a high-fat diet. The Korean Society of Food Science and Nutrition 2023-09-30 2023-09-30 /pmc/articles/PMC10567593/ /pubmed/37842245 http://dx.doi.org/10.3746/pnf.2023.28.3.263 Text en Copyright © 2023 by The Korean Society of Food Science and Nutrition. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original
Yoon, Seon-A
Ham, Young-Min
Han, Sang-Chul
Hyun, Ho Bong
Go, Boram
Jung, Yong-Hwan
Yoo, Eun-Sook
Yoon, Weon-Jong
Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism
title Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism
title_full Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism
title_fullStr Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism
title_full_unstemmed Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism
title_short Immature Persimmon (Diospyros kaki Thunb.) Ethanol Extract Ameliorates High-Fat Diet-Induced Obesity by Modulating Lipid Metabolism
title_sort immature persimmon (diospyros kaki thunb.) ethanol extract ameliorates high-fat diet-induced obesity by modulating lipid metabolism
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567593/
https://www.ncbi.nlm.nih.gov/pubmed/37842245
http://dx.doi.org/10.3746/pnf.2023.28.3.263
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