Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

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The normally antiviral enzyme APOBEC3A is an endogenous mutagen in human cancer. Its single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including signature single-base substitution mutations (isolated and clustered), DNA breakage, and larger-scale chromosomal aberrati...

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Detalles Bibliográficos
Autores principales: Harjes, Stefan, Kurup, Harikrishnan M., Rieffer, Amanda E., Bayarjargal, Maitsetseg, Filitcheva, Jana, Su, Yongdong, Hale, Tracy K., Filichev, Vyacheslav V., Harjes, Elena, Harris, Reuben S., Jameson, Geoffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567711/
https://www.ncbi.nlm.nih.gov/pubmed/37821454
http://dx.doi.org/10.1038/s41467-023-42174-w

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