PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target

Aberrant overexpression or activation of EGFR drives the development of non-small cell lung cancer (NSCLC) and acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) by secondary EGFR mutations or c-MET amplification/activation remains as a major hurdle for NSCLC treatment. We previously iden...

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Detalles Bibliográficos
Autores principales: Singh, Shaifali, Yeat, Nai Yang, Wang, Ya-Ting, Lin, Shu-Yu, Kuo, I-Ying, Wu, Kuen-Phon, Wang, Won-Jing, Wang, Wen-Ching, Su, Wu-Chou, Wang, Yi-Ching, Chen, Ruey-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567730/
https://www.ncbi.nlm.nih.gov/pubmed/37821451
http://dx.doi.org/10.1038/s41419-023-06201-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567730/
https://www.ncbi.nlm.nih.gov/pubmed/37821451
http://dx.doi.org/10.1038/s41419-023-06201-4

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