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A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study

Inherent to any stenting procedure is the prescription of dual antiplatelet therapy (DAPT) to reduce the platelet response. Clinical guidelines recommend 6–12 months of DAPT, depending on stent type, clinical picture and patient factors. Our hypothesis is that a nanostructured noble metal coating ha...

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Autores principales: Sandell, Mikael, Ericsson, Anna, Al-Saadi, Jonathan, Södervall, Billy, Södergren, Erika, Grass, Stefan, Sanchez, Javier, Holmin, Staffan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567768/
https://www.ncbi.nlm.nih.gov/pubmed/37821529
http://dx.doi.org/10.1038/s41598-023-44364-4
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author Sandell, Mikael
Ericsson, Anna
Al-Saadi, Jonathan
Södervall, Billy
Södergren, Erika
Grass, Stefan
Sanchez, Javier
Holmin, Staffan
author_facet Sandell, Mikael
Ericsson, Anna
Al-Saadi, Jonathan
Södervall, Billy
Södergren, Erika
Grass, Stefan
Sanchez, Javier
Holmin, Staffan
author_sort Sandell, Mikael
collection PubMed
description Inherent to any stenting procedure is the prescription of dual antiplatelet therapy (DAPT) to reduce the platelet response. Clinical guidelines recommend 6–12 months of DAPT, depending on stent type, clinical picture and patient factors. Our hypothesis is that a nanostructured noble metal coating has the potential to reduce protein deposition and platelet activation. These effects would reduce subsequent thrombo-inflammatory reactions, potentially mitigating the need for an extensive DAPT in the acute phase. Here, a noble metal nanostructure coating on stents is investigated. Twelve pigs underwent endovascular implantation of coated and non-coated stents for paired comparisons in a blinded study design. The non-coated control stent was placed at the contralateral corresponding artery. Volumetric analysis of angiographic data, performed by a treatment blinded assessor, demonstrated a significant thrombus reduction for one of the coatings compared to control. This effect was already seen one hour after implantation. This finding was supported by in vitro data showing a significant reduction of coagulation activation in the coated group. This novel coating shows promise as an implant material addition and could potentially decrease the need for DAPT in the early phases of stent implementation.
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spelling pubmed-105677682023-10-13 A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study Sandell, Mikael Ericsson, Anna Al-Saadi, Jonathan Södervall, Billy Södergren, Erika Grass, Stefan Sanchez, Javier Holmin, Staffan Sci Rep Article Inherent to any stenting procedure is the prescription of dual antiplatelet therapy (DAPT) to reduce the platelet response. Clinical guidelines recommend 6–12 months of DAPT, depending on stent type, clinical picture and patient factors. Our hypothesis is that a nanostructured noble metal coating has the potential to reduce protein deposition and platelet activation. These effects would reduce subsequent thrombo-inflammatory reactions, potentially mitigating the need for an extensive DAPT in the acute phase. Here, a noble metal nanostructure coating on stents is investigated. Twelve pigs underwent endovascular implantation of coated and non-coated stents for paired comparisons in a blinded study design. The non-coated control stent was placed at the contralateral corresponding artery. Volumetric analysis of angiographic data, performed by a treatment blinded assessor, demonstrated a significant thrombus reduction for one of the coatings compared to control. This effect was already seen one hour after implantation. This finding was supported by in vitro data showing a significant reduction of coagulation activation in the coated group. This novel coating shows promise as an implant material addition and could potentially decrease the need for DAPT in the early phases of stent implementation. Nature Publishing Group UK 2023-10-11 /pmc/articles/PMC10567768/ /pubmed/37821529 http://dx.doi.org/10.1038/s41598-023-44364-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sandell, Mikael
Ericsson, Anna
Al-Saadi, Jonathan
Södervall, Billy
Södergren, Erika
Grass, Stefan
Sanchez, Javier
Holmin, Staffan
A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study
title A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study
title_full A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study
title_fullStr A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study
title_full_unstemmed A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study
title_short A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study
title_sort novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567768/
https://www.ncbi.nlm.nih.gov/pubmed/37821529
http://dx.doi.org/10.1038/s41598-023-44364-4
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