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Effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability – a randomized clinical trial
The aim of this prospective, placebo-controlled, double-blind, randomized, cross-over study was to determine cannabinoid levels in blood and driving-related ability after single (S1) and repetitive (S2) vaporization of cannabis rich in cannabidiol (CBD) containing < 1% Δ(9)-etrahydrocannabinol (T...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567805/ https://www.ncbi.nlm.nih.gov/pubmed/37626214 http://dx.doi.org/10.1007/s00414-023-03076-0 |
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author | Egloff, Laura Frei, Priska Gerlach, Kathrin Mercer-Chalmers-Bender, Katja Scheurer, Eva |
author_facet | Egloff, Laura Frei, Priska Gerlach, Kathrin Mercer-Chalmers-Bender, Katja Scheurer, Eva |
author_sort | Egloff, Laura |
collection | PubMed |
description | The aim of this prospective, placebo-controlled, double-blind, randomized, cross-over study was to determine cannabinoid levels in blood and driving-related ability after single (S1) and repetitive (S2) vaporization of cannabis rich in cannabidiol (CBD) containing < 1% Δ(9)-etrahydrocannabinol (THC). Healthy adult volunteers (N(single) = 27, N(repetitive) = 20) with experience in smoking vapor-inhaled two low-THC/CBD-rich cannabis products both with < 1% THC (product 1: 38 mg CBD, 1.8 mg THC; product 2: 39 mg CBD, 0.6 mg THC) and placebo. Main outcomes were THC- and CBD-levels in whole blood and overall assessment of driving-related ability by computerized tests. Among 74 participants included, 27 (mean age ± SD, 28.9 ± 12.5 years) completed S1, and 20 (25.2 ± 4.0) completed S2. Peak concentrations and duration of detectability depended on the THC-content of the product. After single consumption THC dropped below 1.5 µg/L after 1.5 h, but was detected in some participants up to 5 h. Pairwise comparison of driving-related ability revealed no significant differences between low-THC/CBD-rich products (P1, P2) and placebo. Detection of THC after consumption of low-THC/CBD-rich cannabis might have legal consequences for drivers. Regarding overall driving-related ability, no significant differences were observed between the interventional products. This trial was registered with the German Clinical Trials Register (DRKS00018836) on 25.10.2019 and with the Coordination Office for Human Research (kofam) which is operated by the Federal Office of Public Health (FOPH) (SNCTP000003294). |
format | Online Article Text |
id | pubmed-10567805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-105678052023-10-13 Effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability – a randomized clinical trial Egloff, Laura Frei, Priska Gerlach, Kathrin Mercer-Chalmers-Bender, Katja Scheurer, Eva Int J Legal Med Original Article The aim of this prospective, placebo-controlled, double-blind, randomized, cross-over study was to determine cannabinoid levels in blood and driving-related ability after single (S1) and repetitive (S2) vaporization of cannabis rich in cannabidiol (CBD) containing < 1% Δ(9)-etrahydrocannabinol (THC). Healthy adult volunteers (N(single) = 27, N(repetitive) = 20) with experience in smoking vapor-inhaled two low-THC/CBD-rich cannabis products both with < 1% THC (product 1: 38 mg CBD, 1.8 mg THC; product 2: 39 mg CBD, 0.6 mg THC) and placebo. Main outcomes were THC- and CBD-levels in whole blood and overall assessment of driving-related ability by computerized tests. Among 74 participants included, 27 (mean age ± SD, 28.9 ± 12.5 years) completed S1, and 20 (25.2 ± 4.0) completed S2. Peak concentrations and duration of detectability depended on the THC-content of the product. After single consumption THC dropped below 1.5 µg/L after 1.5 h, but was detected in some participants up to 5 h. Pairwise comparison of driving-related ability revealed no significant differences between low-THC/CBD-rich products (P1, P2) and placebo. Detection of THC after consumption of low-THC/CBD-rich cannabis might have legal consequences for drivers. Regarding overall driving-related ability, no significant differences were observed between the interventional products. This trial was registered with the German Clinical Trials Register (DRKS00018836) on 25.10.2019 and with the Coordination Office for Human Research (kofam) which is operated by the Federal Office of Public Health (FOPH) (SNCTP000003294). Springer Berlin Heidelberg 2023-08-26 2023 /pmc/articles/PMC10567805/ /pubmed/37626214 http://dx.doi.org/10.1007/s00414-023-03076-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Egloff, Laura Frei, Priska Gerlach, Kathrin Mercer-Chalmers-Bender, Katja Scheurer, Eva Effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability – a randomized clinical trial |
title | Effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability – a randomized clinical trial |
title_full | Effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability – a randomized clinical trial |
title_fullStr | Effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability – a randomized clinical trial |
title_full_unstemmed | Effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability – a randomized clinical trial |
title_short | Effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability – a randomized clinical trial |
title_sort | effect of vaporizing cannabis rich in cannabidiol on cannabinoid levels in blood and on driving ability – a randomized clinical trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567805/ https://www.ncbi.nlm.nih.gov/pubmed/37626214 http://dx.doi.org/10.1007/s00414-023-03076-0 |
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