PSMA-617 inhibits proliferation and potentiates the (177)Lu-PSMA-617-induced death of human prostate cancer cells

The human prostate–specific membrane antigen (PSMA) is substantially up-regulated in metastatic prostate cancer (PCa) cells. PSMA can be targeted by (177)Lu conjugated to PSMA-617, a high-affinity ligand for the PSMA. The binding of the radioligand, (177)Lu-PSMA-617, results in its internalisation a...

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Detalles Bibliográficos
Autores principales: Zhao, Yi, Culman, Juraj, Cascorbi, Ingolf, Nithack, Niklas, Marx, Marlies, Zuhayra, Maaz, Lützen, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567812/
https://www.ncbi.nlm.nih.gov/pubmed/37284895
http://dx.doi.org/10.1007/s00210-023-02539-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567812/
https://www.ncbi.nlm.nih.gov/pubmed/37284895
http://dx.doi.org/10.1007/s00210-023-02539-w

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