Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria

β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly described rol...

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Autores principales: Klein, Andrés D., Outeiro, Tiago Fleming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567851/
https://www.ncbi.nlm.nih.gov/pubmed/37821433
http://dx.doi.org/10.1038/s41467-023-42107-7
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author Klein, Andrés D.
Outeiro, Tiago Fleming
author_facet Klein, Andrés D.
Outeiro, Tiago Fleming
author_sort Klein, Andrés D.
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description β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly described role of GCase in the mitochondria will inform new Parkinson’s and Gaucher’s disease therapeutics.
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spelling pubmed-105678512023-10-13 Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria Klein, Andrés D. Outeiro, Tiago Fleming Nat Commun Comment β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly described role of GCase in the mitochondria will inform new Parkinson’s and Gaucher’s disease therapeutics. Nature Publishing Group UK 2023-10-11 /pmc/articles/PMC10567851/ /pubmed/37821433 http://dx.doi.org/10.1038/s41467-023-42107-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Klein, Andrés D.
Outeiro, Tiago Fleming
Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
title Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
title_full Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
title_fullStr Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
title_full_unstemmed Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
title_short Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
title_sort glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567851/
https://www.ncbi.nlm.nih.gov/pubmed/37821433
http://dx.doi.org/10.1038/s41467-023-42107-7
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