USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation

Despite its involvement in various cancers, the function of the deubiquitinase USP1 (ubiquitin-specific protease 1) is unexplored in cholangiocarcinoma (CCA). In this study, we provide evidence that USP1 promotes CCA progression through the stabilization of Poly (ADP-ribose) polymerase 1 (PARP1), co...

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Detalles Bibliográficos
Autores principales: Zhang, Deng Yong, Zhu, Yan, Wu, Qiong, Ma, Shuoshuo, Ma, Yang, Shen, Zheng chao, Wang, Zhonglin, Sun, Wanliang, Zhou, Yong Chun, Wang, Dongdong, Zhou, Shuo, Liu, Zhong, Kwong, Lawrence N., Lu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567853/
https://www.ncbi.nlm.nih.gov/pubmed/37821462
http://dx.doi.org/10.1038/s41419-023-06172-6

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