SARS-CoV-2 infection of human lung epithelial cells induces TMPRSS-mediated acute fibrin deposition

Severe COVID-associated lung injury is a major confounding factor of hospitalizations and death with no effective treatments. Here, we describe a non-classical fibrin clotting mechanism mediated by SARS-CoV-2 infected primary lung but not other susceptible epithelial cells. This infection-induced fi...

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Detalles Bibliográficos
Autores principales: Erickson, Rachel, Huang, Chang, Allen, Cameron, Ireland, Joanna, Roth, Gwynne, Zou, Zhongcheng, Lu, Jinghua, Lafont, Bernard A. P., Garza, Nicole L., Brumbaugh, Beniah, Zhao, Ming, Suzuki, Motoshi, Olano, Lisa, Brzostowski, Joseph, Fischer, Elizabeth R., Twigg, Homer L., Johnson, Reed F., Sun, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567911/
https://www.ncbi.nlm.nih.gov/pubmed/37821447
http://dx.doi.org/10.1038/s41467-023-42140-6

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