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Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review
Type 2 diabetes (T2D) in youth is a global health concern characterized by an increasing incidence and prevalence, especially among disadvantaged socioeconomic subgroups. Moreover, youth-onset T2D is more aggressive and causes earlier, more severe long-term cardio-renal complications compared with T...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Healthcare
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567925/ https://www.ncbi.nlm.nih.gov/pubmed/37668933 http://dx.doi.org/10.1007/s12325-023-02642-7 |
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author | Tamborlane, William Shehadeh, Naim |
author_facet | Tamborlane, William Shehadeh, Naim |
author_sort | Tamborlane, William |
collection | PubMed |
description | Type 2 diabetes (T2D) in youth is a global health concern characterized by an increasing incidence and prevalence, especially among disadvantaged socioeconomic subgroups. Moreover, youth-onset T2D is more aggressive and causes earlier, more severe long-term cardio-renal complications compared with T2D in adults. The therapeutic options available are limited and often inadequate, partially due to the numerous challenges in implementing clinical trials for this vulnerable patient population. Over the last few years, a significant effort has been made to develop new effective drugs for children and adolescents with T2D. Specifically, a number of studies are currently generating new data to address the urgent unmet medical need for optimal management of this disease. This review describes the central features of youth-onset T2D and summarizes the available treatments and ongoing studies in pediatric patients. |
format | Online Article Text |
id | pubmed-10567925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-105679252023-10-13 Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review Tamborlane, William Shehadeh, Naim Adv Ther Review Type 2 diabetes (T2D) in youth is a global health concern characterized by an increasing incidence and prevalence, especially among disadvantaged socioeconomic subgroups. Moreover, youth-onset T2D is more aggressive and causes earlier, more severe long-term cardio-renal complications compared with T2D in adults. The therapeutic options available are limited and often inadequate, partially due to the numerous challenges in implementing clinical trials for this vulnerable patient population. Over the last few years, a significant effort has been made to develop new effective drugs for children and adolescents with T2D. Specifically, a number of studies are currently generating new data to address the urgent unmet medical need for optimal management of this disease. This review describes the central features of youth-onset T2D and summarizes the available treatments and ongoing studies in pediatric patients. Springer Healthcare 2023-09-05 2023 /pmc/articles/PMC10567925/ /pubmed/37668933 http://dx.doi.org/10.1007/s12325-023-02642-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Review Tamborlane, William Shehadeh, Naim Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review |
title | Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review |
title_full | Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review |
title_fullStr | Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review |
title_full_unstemmed | Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review |
title_short | Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review |
title_sort | unmet needs in the treatment of childhood type 2 diabetes: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567925/ https://www.ncbi.nlm.nih.gov/pubmed/37668933 http://dx.doi.org/10.1007/s12325-023-02642-7 |
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