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Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review

Type 2 diabetes (T2D) in youth is a global health concern characterized by an increasing incidence and prevalence, especially among disadvantaged socioeconomic subgroups. Moreover, youth-onset T2D is more aggressive and causes earlier, more severe long-term cardio-renal complications compared with T...

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Detalles Bibliográficos
Autores principales: Tamborlane, William, Shehadeh, Naim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567925/
https://www.ncbi.nlm.nih.gov/pubmed/37668933
http://dx.doi.org/10.1007/s12325-023-02642-7
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author Tamborlane, William
Shehadeh, Naim
author_facet Tamborlane, William
Shehadeh, Naim
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description Type 2 diabetes (T2D) in youth is a global health concern characterized by an increasing incidence and prevalence, especially among disadvantaged socioeconomic subgroups. Moreover, youth-onset T2D is more aggressive and causes earlier, more severe long-term cardio-renal complications compared with T2D in adults. The therapeutic options available are limited and often inadequate, partially due to the numerous challenges in implementing clinical trials for this vulnerable patient population. Over the last few years, a significant effort has been made to develop new effective drugs for children and adolescents with T2D. Specifically, a number of studies are currently generating new data to address the urgent unmet medical need for optimal management of this disease. This review describes the central features of youth-onset T2D and summarizes the available treatments and ongoing studies in pediatric patients.
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spelling pubmed-105679252023-10-13 Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review Tamborlane, William Shehadeh, Naim Adv Ther Review Type 2 diabetes (T2D) in youth is a global health concern characterized by an increasing incidence and prevalence, especially among disadvantaged socioeconomic subgroups. Moreover, youth-onset T2D is more aggressive and causes earlier, more severe long-term cardio-renal complications compared with T2D in adults. The therapeutic options available are limited and often inadequate, partially due to the numerous challenges in implementing clinical trials for this vulnerable patient population. Over the last few years, a significant effort has been made to develop new effective drugs for children and adolescents with T2D. Specifically, a number of studies are currently generating new data to address the urgent unmet medical need for optimal management of this disease. This review describes the central features of youth-onset T2D and summarizes the available treatments and ongoing studies in pediatric patients. Springer Healthcare 2023-09-05 2023 /pmc/articles/PMC10567925/ /pubmed/37668933 http://dx.doi.org/10.1007/s12325-023-02642-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Tamborlane, William
Shehadeh, Naim
Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review
title Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review
title_full Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review
title_fullStr Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review
title_full_unstemmed Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review
title_short Unmet Needs in the Treatment of Childhood Type 2 Diabetes: A Narrative Review
title_sort unmet needs in the treatment of childhood type 2 diabetes: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567925/
https://www.ncbi.nlm.nih.gov/pubmed/37668933
http://dx.doi.org/10.1007/s12325-023-02642-7
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