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Peripheral temperature dysregulation associated with functionally altered Na(V)1.8 channels

The voltage-gated sodium channel Na(V)1.8 is prominently expressed in the soma and axons of small-caliber sensory neurons, and pathogenic variants of the corresponding gene SCN10A are associated with peripheral pain and autonomic dysfunction. While most disease-associated SCN10A variants confer gain...

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Detalles Bibliográficos
Autores principales: Loose, Simon, Lischka, Annette, Kuehs, Samuel, Nau, Carla, Heinemann, Stefan H., Kurth, Ingo, Leipold, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567936/
https://www.ncbi.nlm.nih.gov/pubmed/37695396
http://dx.doi.org/10.1007/s00424-023-02856-2