A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives

INTRODUCTION: The neurotrophin system plays a pivotal role in the development, morphology, and survival of the nervous system, and its dysregulation has been manifested in numerous neurodegenerative and neuroinflammatory diseases. Neurotrophins NGF and BDNF are major growth factors that prevent neur...

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Detalles Bibliográficos
Autores principales: Narducci, Daniele, Charou, Despoina, Rogdakis, Thanasis, Zota, Ioanna, Bafiti, Vivi, Zervou, Maria, Katsila, Theodora, Gravanis, Achille, Prousis, Kyriakos C., Charalampopoulos, Ioannis, Calogeropoulou, Theodora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568017/
https://www.ncbi.nlm.nih.gov/pubmed/37840771
http://dx.doi.org/10.3389/fnmol.2023.1244133

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