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Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control
INTRODUCTION: Previous neuroimaging evidence highlighted the role of the insular and dorsal anterior cingulate cortex (dACC) in conflict monitoring and decision-making, thus supporting the translational implications of targeting these regions in neuro-stimulation treatments for clinical purposes. Re...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568024/ https://www.ncbi.nlm.nih.gov/pubmed/37840546 http://dx.doi.org/10.3389/fnbeh.2023.1234837 |
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author | Gorrino, Irene Canessa, Nicola Mattavelli, Giulia |
author_facet | Gorrino, Irene Canessa, Nicola Mattavelli, Giulia |
author_sort | Gorrino, Irene |
collection | PubMed |
description | INTRODUCTION: Previous neuroimaging evidence highlighted the role of the insular and dorsal anterior cingulate cortex (dACC) in conflict monitoring and decision-making, thus supporting the translational implications of targeting these regions in neuro-stimulation treatments for clinical purposes. Recent advancements of targeting and modeling procedures for high-definition tDCS (HD-tDCS) provided methodological support for the stimulation of otherwise challenging targets, and a previous study confirmed that cathodal HD-tDCS of the dACC modulates executive control and decision-making metrics in healthy individuals. On the other hand, evidence on the effect of stimulating the insula is still needed. METHODS: We used a modeling/targeting procedure to investigate the effect of stimulating the posterior insula on Flanker and gambling tasks assessing, respectively, executive control and both loss and risk aversion in decision-making. HD-tDCS was applied through 6 small electrodes delivering anodal, cathodal or sham stimulation for 20 min in a within-subject offline design with three separate sessions. RESULTS: Bayesian statistical analyses on Flanker conflict effect, as well as loss and risk aversion, provided moderate evidence for the null model (i.e., absence of HD-tDCS modulation). DISCUSSION: These findings suggest that further research on the effect of HD-tDCS on different regions is required to define reliable targets for clinical applications. While modeling and targeting procedures for neuromodulation in clinical research could lead to innovative protocols for stand-alone treatment, or possibly in combination with cognitive training, assessing the effectiveness of insula stimulation might require sensitive metrics other than those investigated here. |
format | Online Article Text |
id | pubmed-10568024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105680242023-10-13 Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control Gorrino, Irene Canessa, Nicola Mattavelli, Giulia Front Behav Neurosci Behavioral Neuroscience INTRODUCTION: Previous neuroimaging evidence highlighted the role of the insular and dorsal anterior cingulate cortex (dACC) in conflict monitoring and decision-making, thus supporting the translational implications of targeting these regions in neuro-stimulation treatments for clinical purposes. Recent advancements of targeting and modeling procedures for high-definition tDCS (HD-tDCS) provided methodological support for the stimulation of otherwise challenging targets, and a previous study confirmed that cathodal HD-tDCS of the dACC modulates executive control and decision-making metrics in healthy individuals. On the other hand, evidence on the effect of stimulating the insula is still needed. METHODS: We used a modeling/targeting procedure to investigate the effect of stimulating the posterior insula on Flanker and gambling tasks assessing, respectively, executive control and both loss and risk aversion in decision-making. HD-tDCS was applied through 6 small electrodes delivering anodal, cathodal or sham stimulation for 20 min in a within-subject offline design with three separate sessions. RESULTS: Bayesian statistical analyses on Flanker conflict effect, as well as loss and risk aversion, provided moderate evidence for the null model (i.e., absence of HD-tDCS modulation). DISCUSSION: These findings suggest that further research on the effect of HD-tDCS on different regions is required to define reliable targets for clinical applications. While modeling and targeting procedures for neuromodulation in clinical research could lead to innovative protocols for stand-alone treatment, or possibly in combination with cognitive training, assessing the effectiveness of insula stimulation might require sensitive metrics other than those investigated here. Frontiers Media S.A. 2023-09-28 /pmc/articles/PMC10568024/ /pubmed/37840546 http://dx.doi.org/10.3389/fnbeh.2023.1234837 Text en Copyright © 2023 Gorrino, Canessa and Mattavelli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Behavioral Neuroscience Gorrino, Irene Canessa, Nicola Mattavelli, Giulia Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control |
title | Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control |
title_full | Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control |
title_fullStr | Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control |
title_full_unstemmed | Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control |
title_short | Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control |
title_sort | testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control |
topic | Behavioral Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568024/ https://www.ncbi.nlm.nih.gov/pubmed/37840546 http://dx.doi.org/10.3389/fnbeh.2023.1234837 |
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