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Rapid rewarming rate associated with favorable neurological outcomes in patients with post–cardiac arrest syndrome patients treated with targeted temperature management
AIM: To determine whether the rewarming rate is associated with neurological outcomes in patients with post–cardiac arrest syndrome treated with targeted temperature management (TTM) at 34°C. METHODS: We conducted a retrospective analysis of a nationwide cohort study of out‐of‐hospital cardiac arres...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568044/ https://www.ncbi.nlm.nih.gov/pubmed/37841965 http://dx.doi.org/10.1002/ams2.897 |
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author | Shin, Masaru Fujita, Motoki Hifumi, Toru Koga, Yasutaka Yagi, Takeshi Nakahara, Takashi Todani, Masaki Kaneda, Kotaro Tsuruta, Ryosuke |
author_facet | Shin, Masaru Fujita, Motoki Hifumi, Toru Koga, Yasutaka Yagi, Takeshi Nakahara, Takashi Todani, Masaki Kaneda, Kotaro Tsuruta, Ryosuke |
author_sort | Shin, Masaru |
collection | PubMed |
description | AIM: To determine whether the rewarming rate is associated with neurological outcomes in patients with post–cardiac arrest syndrome treated with targeted temperature management (TTM) at 34°C. METHODS: We conducted a retrospective analysis of a nationwide cohort study of out‐of‐hospital cardiac arrest in Japan. Adult patients who experienced a return of spontaneous circulation and completed TTM at 34°C between June 2014 and December 2019 were divided equally into three groups (slow, moderate, and rapid) according to their rewarming rates from 34°C to 36°C. The rates of favorable neurological outcomes (Cerebral Performance Category of 1–2 after 30 days) were compared among the groups, and the adjusted odds ratios for a favorable neurological outcome were calculated for the groups. RESULTS: We analyzed 348, 357, and 358 patients in the slow, moderate, and rapid groups, respectively. The periods of rewarming from 34°C to 36°C were 41.9 ± 10.5, 22.4 ± 1.8, and 12.2 ± 3.6 h, respectively. The number of favorable neurological outcomes after 30 days was 121 (34.8%), 125 (35.0%), and 147 (41.1%), respectively, with no significant differences among the three groups (p = 0.145). Rapid rewarming was independently associated with a favorable neurological outcome compared with slow rewarming (adjusted odds ratio 1.57 [95% confidence interval 1.04–2.37]; p = 0.031). CONCLUSIONS: Rapid rewarming after TTM at 34°C was associated with a more favorable neurological outcome than slow rewarming. |
format | Online Article Text |
id | pubmed-10568044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105680442023-10-13 Rapid rewarming rate associated with favorable neurological outcomes in patients with post–cardiac arrest syndrome patients treated with targeted temperature management Shin, Masaru Fujita, Motoki Hifumi, Toru Koga, Yasutaka Yagi, Takeshi Nakahara, Takashi Todani, Masaki Kaneda, Kotaro Tsuruta, Ryosuke Acute Med Surg Original Articles AIM: To determine whether the rewarming rate is associated with neurological outcomes in patients with post–cardiac arrest syndrome treated with targeted temperature management (TTM) at 34°C. METHODS: We conducted a retrospective analysis of a nationwide cohort study of out‐of‐hospital cardiac arrest in Japan. Adult patients who experienced a return of spontaneous circulation and completed TTM at 34°C between June 2014 and December 2019 were divided equally into three groups (slow, moderate, and rapid) according to their rewarming rates from 34°C to 36°C. The rates of favorable neurological outcomes (Cerebral Performance Category of 1–2 after 30 days) were compared among the groups, and the adjusted odds ratios for a favorable neurological outcome were calculated for the groups. RESULTS: We analyzed 348, 357, and 358 patients in the slow, moderate, and rapid groups, respectively. The periods of rewarming from 34°C to 36°C were 41.9 ± 10.5, 22.4 ± 1.8, and 12.2 ± 3.6 h, respectively. The number of favorable neurological outcomes after 30 days was 121 (34.8%), 125 (35.0%), and 147 (41.1%), respectively, with no significant differences among the three groups (p = 0.145). Rapid rewarming was independently associated with a favorable neurological outcome compared with slow rewarming (adjusted odds ratio 1.57 [95% confidence interval 1.04–2.37]; p = 0.031). CONCLUSIONS: Rapid rewarming after TTM at 34°C was associated with a more favorable neurological outcome than slow rewarming. John Wiley and Sons Inc. 2023-10-11 /pmc/articles/PMC10568044/ /pubmed/37841965 http://dx.doi.org/10.1002/ams2.897 Text en © 2023 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Shin, Masaru Fujita, Motoki Hifumi, Toru Koga, Yasutaka Yagi, Takeshi Nakahara, Takashi Todani, Masaki Kaneda, Kotaro Tsuruta, Ryosuke Rapid rewarming rate associated with favorable neurological outcomes in patients with post–cardiac arrest syndrome patients treated with targeted temperature management |
title | Rapid rewarming rate associated with favorable neurological outcomes in patients with post–cardiac arrest syndrome patients treated with targeted temperature management |
title_full | Rapid rewarming rate associated with favorable neurological outcomes in patients with post–cardiac arrest syndrome patients treated with targeted temperature management |
title_fullStr | Rapid rewarming rate associated with favorable neurological outcomes in patients with post–cardiac arrest syndrome patients treated with targeted temperature management |
title_full_unstemmed | Rapid rewarming rate associated with favorable neurological outcomes in patients with post–cardiac arrest syndrome patients treated with targeted temperature management |
title_short | Rapid rewarming rate associated with favorable neurological outcomes in patients with post–cardiac arrest syndrome patients treated with targeted temperature management |
title_sort | rapid rewarming rate associated with favorable neurological outcomes in patients with post–cardiac arrest syndrome patients treated with targeted temperature management |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568044/ https://www.ncbi.nlm.nih.gov/pubmed/37841965 http://dx.doi.org/10.1002/ams2.897 |
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