Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

Disease-causing premature termination codons (PTCs) individually disrupt the functional expression of hundreds of genes and represent a pernicious clinical challenge. In the heart, loss-of-function mutations in the hERG potassium channel account for approximately 30% of long-QT syndrome arrhythmia,...

Descripción completa

Detalles Bibliográficos
Autores principales: Blomquist, Viggo G., Niu, Jacqueline, Choudhury, Papiya, Al Saneh, Ahmad, Colecraft, Henry M., Ahern, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568093/
https://www.ncbi.nlm.nih.gov/pubmed/37842167
http://dx.doi.org/10.1016/j.omtn.2023.102032

Ejemplares similares

Ejemplares similares