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Optimal control dynamics of Gonorrhea in a structured population

Gonorrhea is a serious global health problem due to its high incidence, with approximately 82.4 million new cases in 2020. To evaluate the consequences of targeted dynamic control of gonorrhea infection transmission, a model for gonorrhea with optimal control analysis is proposed for a structured po...

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Autores principales: Asamoah, Joshua Kiddy K., Safianu, Beilawu, Afrifa, Emmanuel, Obeng, Benjamin, Seidu, Baba, Wireko, Fredrick Asenso, Sun, Gui-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568113/
https://www.ncbi.nlm.nih.gov/pubmed/37842629
http://dx.doi.org/10.1016/j.heliyon.2023.e20531
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author Asamoah, Joshua Kiddy K.
Safianu, Beilawu
Afrifa, Emmanuel
Obeng, Benjamin
Seidu, Baba
Wireko, Fredrick Asenso
Sun, Gui-Quan
author_facet Asamoah, Joshua Kiddy K.
Safianu, Beilawu
Afrifa, Emmanuel
Obeng, Benjamin
Seidu, Baba
Wireko, Fredrick Asenso
Sun, Gui-Quan
author_sort Asamoah, Joshua Kiddy K.
collection PubMed
description Gonorrhea is a serious global health problem due to its high incidence, with approximately 82.4 million new cases in 2020. To evaluate the consequences of targeted dynamic control of gonorrhea infection transmission, a model for gonorrhea with optimal control analysis is proposed for a structured population. The study looked at the model's positively invariant and bounded regions. The gonorrhea secondary infection expression, [Formula: see text] for the structured population is computed. The maximum principle of Pontryagin is utilised to construct the optimal system for the formulated mathematical model. To reduce the continuous propagation of gonorrhea, we incorporated education, condoms usage, vaccinations, and treatment as control strategies. The numerical simulations show that the number of infections decreases when the controls are implemented. The effectiveness of the controls is shown using the efficacy plots.
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spelling pubmed-105681132023-10-13 Optimal control dynamics of Gonorrhea in a structured population Asamoah, Joshua Kiddy K. Safianu, Beilawu Afrifa, Emmanuel Obeng, Benjamin Seidu, Baba Wireko, Fredrick Asenso Sun, Gui-Quan Heliyon Research Article Gonorrhea is a serious global health problem due to its high incidence, with approximately 82.4 million new cases in 2020. To evaluate the consequences of targeted dynamic control of gonorrhea infection transmission, a model for gonorrhea with optimal control analysis is proposed for a structured population. The study looked at the model's positively invariant and bounded regions. The gonorrhea secondary infection expression, [Formula: see text] for the structured population is computed. The maximum principle of Pontryagin is utilised to construct the optimal system for the formulated mathematical model. To reduce the continuous propagation of gonorrhea, we incorporated education, condoms usage, vaccinations, and treatment as control strategies. The numerical simulations show that the number of infections decreases when the controls are implemented. The effectiveness of the controls is shown using the efficacy plots. Elsevier 2023-10-04 /pmc/articles/PMC10568113/ /pubmed/37842629 http://dx.doi.org/10.1016/j.heliyon.2023.e20531 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Asamoah, Joshua Kiddy K.
Safianu, Beilawu
Afrifa, Emmanuel
Obeng, Benjamin
Seidu, Baba
Wireko, Fredrick Asenso
Sun, Gui-Quan
Optimal control dynamics of Gonorrhea in a structured population
title Optimal control dynamics of Gonorrhea in a structured population
title_full Optimal control dynamics of Gonorrhea in a structured population
title_fullStr Optimal control dynamics of Gonorrhea in a structured population
title_full_unstemmed Optimal control dynamics of Gonorrhea in a structured population
title_short Optimal control dynamics of Gonorrhea in a structured population
title_sort optimal control dynamics of gonorrhea in a structured population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568113/
https://www.ncbi.nlm.nih.gov/pubmed/37842629
http://dx.doi.org/10.1016/j.heliyon.2023.e20531
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