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Optimal control dynamics of Gonorrhea in a structured population
Gonorrhea is a serious global health problem due to its high incidence, with approximately 82.4 million new cases in 2020. To evaluate the consequences of targeted dynamic control of gonorrhea infection transmission, a model for gonorrhea with optimal control analysis is proposed for a structured po...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568113/ https://www.ncbi.nlm.nih.gov/pubmed/37842629 http://dx.doi.org/10.1016/j.heliyon.2023.e20531 |
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author | Asamoah, Joshua Kiddy K. Safianu, Beilawu Afrifa, Emmanuel Obeng, Benjamin Seidu, Baba Wireko, Fredrick Asenso Sun, Gui-Quan |
author_facet | Asamoah, Joshua Kiddy K. Safianu, Beilawu Afrifa, Emmanuel Obeng, Benjamin Seidu, Baba Wireko, Fredrick Asenso Sun, Gui-Quan |
author_sort | Asamoah, Joshua Kiddy K. |
collection | PubMed |
description | Gonorrhea is a serious global health problem due to its high incidence, with approximately 82.4 million new cases in 2020. To evaluate the consequences of targeted dynamic control of gonorrhea infection transmission, a model for gonorrhea with optimal control analysis is proposed for a structured population. The study looked at the model's positively invariant and bounded regions. The gonorrhea secondary infection expression, [Formula: see text] for the structured population is computed. The maximum principle of Pontryagin is utilised to construct the optimal system for the formulated mathematical model. To reduce the continuous propagation of gonorrhea, we incorporated education, condoms usage, vaccinations, and treatment as control strategies. The numerical simulations show that the number of infections decreases when the controls are implemented. The effectiveness of the controls is shown using the efficacy plots. |
format | Online Article Text |
id | pubmed-10568113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105681132023-10-13 Optimal control dynamics of Gonorrhea in a structured population Asamoah, Joshua Kiddy K. Safianu, Beilawu Afrifa, Emmanuel Obeng, Benjamin Seidu, Baba Wireko, Fredrick Asenso Sun, Gui-Quan Heliyon Research Article Gonorrhea is a serious global health problem due to its high incidence, with approximately 82.4 million new cases in 2020. To evaluate the consequences of targeted dynamic control of gonorrhea infection transmission, a model for gonorrhea with optimal control analysis is proposed for a structured population. The study looked at the model's positively invariant and bounded regions. The gonorrhea secondary infection expression, [Formula: see text] for the structured population is computed. The maximum principle of Pontryagin is utilised to construct the optimal system for the formulated mathematical model. To reduce the continuous propagation of gonorrhea, we incorporated education, condoms usage, vaccinations, and treatment as control strategies. The numerical simulations show that the number of infections decreases when the controls are implemented. The effectiveness of the controls is shown using the efficacy plots. Elsevier 2023-10-04 /pmc/articles/PMC10568113/ /pubmed/37842629 http://dx.doi.org/10.1016/j.heliyon.2023.e20531 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Asamoah, Joshua Kiddy K. Safianu, Beilawu Afrifa, Emmanuel Obeng, Benjamin Seidu, Baba Wireko, Fredrick Asenso Sun, Gui-Quan Optimal control dynamics of Gonorrhea in a structured population |
title | Optimal control dynamics of Gonorrhea in a structured population |
title_full | Optimal control dynamics of Gonorrhea in a structured population |
title_fullStr | Optimal control dynamics of Gonorrhea in a structured population |
title_full_unstemmed | Optimal control dynamics of Gonorrhea in a structured population |
title_short | Optimal control dynamics of Gonorrhea in a structured population |
title_sort | optimal control dynamics of gonorrhea in a structured population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568113/ https://www.ncbi.nlm.nih.gov/pubmed/37842629 http://dx.doi.org/10.1016/j.heliyon.2023.e20531 |
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