Turning up the heat on essential E. coli genes

Temperature‐sensitive (TS) alleles create tunable thermoswitches to deplete essential cellular activities and are used to dissect gene function. In their recent study, Link and colleagues (Schramm et al 2023) use a CRISPR‐based approach to systematically create TS alleles across essential genes in E...

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Detalles Bibliográficos
Autores principales: Kumar, Arun, Stirling, Peter C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568200/
https://www.ncbi.nlm.nih.gov/pubmed/37718698
http://dx.doi.org/10.15252/msb.202311933
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author Kumar, Arun
Stirling, Peter C
author_facet Kumar, Arun
Stirling, Peter C
author_sort Kumar, Arun
collection PubMed
description Temperature‐sensitive (TS) alleles create tunable thermoswitches to deplete essential cellular activities and are used to dissect gene function. In their recent study, Link and colleagues (Schramm et al 2023) use a CRISPR‐based approach to systematically create TS alleles across essential genes in E. coli.
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spelling pubmed-105682002023-10-13 Turning up the heat on essential E. coli genes Kumar, Arun Stirling, Peter C Mol Syst Biol News & Views Temperature‐sensitive (TS) alleles create tunable thermoswitches to deplete essential cellular activities and are used to dissect gene function. In their recent study, Link and colleagues (Schramm et al 2023) use a CRISPR‐based approach to systematically create TS alleles across essential genes in E. coli. John Wiley and Sons Inc. 2023-09-18 /pmc/articles/PMC10568200/ /pubmed/37718698 http://dx.doi.org/10.15252/msb.202311933 Text en © 2023 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Kumar, Arun
Stirling, Peter C
Turning up the heat on essential E. coli genes
title Turning up the heat on essential E. coli genes
title_full Turning up the heat on essential E. coli genes
title_fullStr Turning up the heat on essential E. coli genes
title_full_unstemmed Turning up the heat on essential E. coli genes
title_short Turning up the heat on essential E. coli genes
title_sort turning up the heat on essential e. coli genes
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568200/
https://www.ncbi.nlm.nih.gov/pubmed/37718698
http://dx.doi.org/10.15252/msb.202311933
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