Toward non-factor therapy in hemophilia: an antithrombin insensitive Gla-domainless factor Xa as tissue factor pathway inhibitor bait

BACKGROUND: Gla-domainless factor (F) Xa (GD-FXa) was proposed as a trap to endogenous anticoagulant tissue factor pathway inhibitor (TFPI) to restore thrombin generation in hemophilia. Using computational chemistry and experimental approaches, we previously showed that S195A GD-FXa also binds TFPI...

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Detalles Bibliográficos
Autores principales: Dagher, Marie-Claire, Ersayin, Atanur, Seyve, Landry, Castellan, Mathieu, Moreau, Cyril, Choisnard, Luc, Thielens, Nicole, Marlu, Raphaël, Polack, Benoît, Thomas, Aline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568284/
https://www.ncbi.nlm.nih.gov/pubmed/37841511
http://dx.doi.org/10.1016/j.rpth.2023.102175

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